Study on the Quality Evaluation of Xiaoer Huatan Zhike Granules Based on the Content Determination of Four Indexes Components
Objective:To evaluate the quality of Xiaoer Huatan Zhike granules based on the content determination of 4 index compo-nents.Methods:The contents of ephedrine hydrochloride,emetine,Cephaeline,mulberroside A were determind by HPLC based on termi-nal absorption.Results:The linear ranges of ephedrine hydrochloride,emetine,Cephaeline and mulberroside A were 33.0-495.0 µg·mL-1(r2=1.000 0),9.1-136.2 μg·mL-1(r2=1.000 0),2.6-39.2 µg·mL-1(r2=0.999 7)、8.2-123.6 µg·mL-1(r2=0.997 7),respectively;the average recoveries were 99%(RSD=1.04%),99%(RSD=1.07%),96%(RSD=1.42%),94%(RSD=2.27%)respectively.Conclusion:This method has strong specificity,high accuracy and good reproducibility.It can be used for the quality control for Xiaoer Huatan Zhike granules.