Effect of Yishen Huashi Granule on clinical parameters and HIF-1α in patients with diabetic nephropathy
Objective To explore the effects of Yishen Huashi Granule on clinical parameters and serum hypoxia inducible factor-1α(HIF-1α)in patients with type 2 diabetic nephropathy.Methods From November 2020 to December 2021,sixty patients with diabetic nephropathy(30 cases in experimental group and 30 cases in control group)were selected.Patients with type 2 diabetic nephropathy were assigned to the oral Yishen Huashi Granule group three times a day(experimental group)or the non-Yishen Huashi Granule group(control group),fol-lowed up for 12 weeks.The blood glucose(fasting blood glucose,glycosylated hemoglobin),blood lipid(choles-terol,triglyceride,low density lipoprotein),kidney function(creatinine,urea nitrogen,uric acid,β2-microglobulin),and UAER,HIF-1α of the experimental group and the non-experimental group were calculated and compared.Results After treatment,the creatinine[(102±34)µmol/L vs(162±148)μmol/L]and[32 microglobulin[(4.9±2.1)mg/L vs(7.5±5.4)mg/L]and eGFR[(74±26)ml·min-1·1.73 m-2 vs(59±34)ml·min-1·1.73 m-2]in the experimental group were lower than those in the non-experimental group,and the differences between two groups were statistically significant(t=-2.81,-2.43,3.12,all P＜0.05).The effective rate of TCM syndromes in the experimental group was 77％,while that in the non-experimental group was 40％,thex2 test showed statistical significance(x2=8.297,P=0.004).The effective rates of clinical comprehensive curative effect analysis of experimental group and non-ex-perimental group were 77％and 37％,respectively,which were statistically significant by x2 test(x2=9.77,P=0.002).Conclusion Yishen Huashi Granule can effectively delay the progress of renal function in patients with diabetic nephropathy.At present,it has not been concluded that Yishen Huashi Granule can exert renal protective effect on diabetic nephropathy patients by inhibiting HIF-1α.
万方数据
维普
