Correlation of metabolic indexes in patients with central amenorrhea
Objective To explore the incidence of metabolic abnormalities in patients with central amenorrhea,and the correlation between metabolic abnormalities and hyperhomocysteinemia(HHcy)and abnormal glucose metabolism.Methods A retrospective analysis of 60 patients with central amenorrhea in the outpatient clinic of the Department of Reproductive Endocrinology of Taiyuan Maternal and Child Health Hospital from December 1,2021 to June 1,2022 was performed as the study population,as well as 60 cases of women with normal checkups during the same period of time,all of whom were 14 to 40 years old.Firstly,their blood pressure was measured and body composition was analyzed,and their blood was drawn to determine thyroid function,homocysteine(Hcy),uric acid,liver function,renal function,blood fat,glucose tolerance test and insulin release test.Finally,we compared and analyzed the incidence of metabolic abnormalities in 60 patients with central amenorrhea,and which metabolic indexes were related to Hcy and glucose metabolism.Results The incidence of HHcy(87％vs 57％),abnormal glucose metabolism(93％vs 50％),total cholesterol(30％vs 13％),triglycerides(37％vs 8％)and high-density lipoprotein(40％vs 17％)abnormalities in 60 patients with central amenorrhea were significantly higher than those in 60 normal controls(P＜0.05).In the correlation analysis between central amenorrhea and various factors,it is indicated that the risk factors for central amenorrhea were the occurrence of abnormal glucose metabolism,high Hcy,and hypertriglyceridemia.Conclusion Patients with central amenorrhea are at high risk of HHcy,abnormal glucose metabolism and hypercholesterolemia.Therefore,it is suggested that patients with central amenorrhea should be routinely examined for Hcy,glucose metabolism and other metabolic related indicators,which is important for guiding the formulation of comprehensive treatment plan.
万方数据
维普
