Effect of different doses of ursodeoxycholic acid on biochemical and immunological indices in the treat-ment of primary biliary cholangitis
Objective To investigate the effects of different doses of ursodeoxycholic acid on biochemical and immunological indices in the treatment of primary biliary cholangitis.Methods A total of eighty-four patients with primary biliary cholangitis,who were diagnosed and treated in our hospital from August 2021 to December 2022,were selected for retrospective analysis.They were divided into a low-dose group and a high-dose group ac-cording to the random number table method,with 42 patients in each group.The low-dose group received ur-sodeoxycholic acid at a dose of 14～16 mg/kg,while the high-dose group received ursodeoxycholic acid at a dose of 29～31 mg/kg.The clinical effects,biochemical indexes(including alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),gamma-glutamyl transpeptidase(GGT),serum total bilirubin(TBIL),and serum direct bilirubin(DBIL),oxidative stress indicators[including glutathione peroxidase(GSH-Px),malondialdehyde(MDA),and superoxide dismutase(SOD)],immunological indicators[including immunoglobulin M(IgM)and immunoglobulin A(IgA)],and adverse reactions associated with different dosages of ursodeoxycholic acid treatment were observed.Results The effective rate of the low-dose group was 55％(23 cases were effec-tive),the effective rate of the high-dose group was 24％(10 cases were effective).The effective rate was signifi-cantly higher in the low-dose group than that in the high-dose group(x2=8.435,P＜0.05).The levels of ALT,AST,ALP,GGT,TBIL and DBIL in the two groups after treatment were significantly lower than those before treatment(low-dose group:t=41.217,38.201,36.206,31.309,9.859,11.262,all P＜0.01;high-dose group:t=36.334,30.622,30.422,24.247,5.589,4.167,all P＜0.01).The levels of ALT,AST,ALP,GGT,TBIL and DBIL in the low-dose group were significantly lower than those in the high-dose group(t=9.456,12.917,1 1.166,7.930,7.469,4.854,all P＜0.01).After treatment,the levels of IgM and IgA in the low-dose group were lower than those in the high-dose group(t=2.832.4.561,P＜0.05).After treatment,the levels of GSH Px and SOD in the low-dose group were signif-icantly higher than those in the high-dose group(t=9.195,5.009,P＜0.05),and the levels of MDA were significant-ly lower than those in the high-dose group(t=8.397,P＜0.001).The incidence of adverse reactions in the low-dose group was 5％,while it was 19％in the high-dose group.The incidence of adverse reactions in the low-dose group was significantly lower than that in the high-dose group(x2=4.087,P=0.043).Conclusion Low-dose ursodeoxy-cholic acid is more effective and safe in the treatment of primary biliary cholangitis,and it can effectively improve liver function,reduce oxidative stress and enhance the immune function.
万方数据
维普
