Efficacy of oral administration of Bifidobacterium combined with IVIG and blue light irradiation on neonatal ABO hemolytic jaundice
Objective To investigate the efficacy of oral administration of Bifidobacterium combined with intravenous immunoglobulin(IVIG)and blue light irradiation in the treatment of neonatal ABO hemolytic jaundice.Methods A total of 103 neonates with ABO hemolytic jaundice admitted to Wenzhou Central Hospital from Jan-uary 2020 to January 2023 were selected.They were divided into a control group[51 cases,treated with intrave-nous immunoglobulin(IVIG)combined with blue light irradiation]and an observation group(52 cases,treated with oral Bifidobacterium combined with IVIG and blue light irradiation)depending on the treatment method.Compare the clinical efficacy,transcutaneous bilirubin values,myocardial enzymes profiles,liver function indicators,and adverse effects between the two groups.Results The time for jaundice disappearing,the first defecation time,and the time for meconium turning to yellow in the observation group were shorter than that in the control group(P＜0.05).After 3,5 and 7 days of treatment,the transcutaneous bilirubin level decreased,and the values were lower in the observation group compared to the control group(P＜0.05).After treatment,the activities of myocardial en-zymes decreased significantly.The levels of serum creatine kinase isoenzyme(CK-MB),creatine kinase(CK),lac-tate dehydrogenase(LDH),and aspartate transaminase(AST)were lower in the observation group compared to the control group(P＜0.05).Adverse reaction incidence rate was similar between both groups(P＞0.05).Conclusion Oral administration of Bifidobacterium combined with IVIG and blue light irradiation can improve the clinical therapeutic effect on neonatal ABO hemolytic jaundice.This therapy can effectively shorten the time for jaundice disappearing,reduce transcutaneous bilirubin levels,and promote the recovery of myocardial and liver tissues.This treatment is safe and reliable,and has recommended value.
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