Research progress of aspirin in preventing preeclampsia
Aspirin is a non-steroidal anti-inflammatory drug that acts by non-selective and irreversible inhibition of cyclooxygenase(COX),thereby suppressing the production of prostaglandins and thromboxanes and inhibiting platelet aggregation.Aspirin also inhibits hypoxia-induced overexpression of soluble fms-like tyrosine kinase-1 by inhibiting COX-1.Additionally,Aspirin enhances the proliferation and invasion while inhibiting apoptosis of trophoblasts.Preeclampsia is a complex multi-system disorder diagnosed by sudden onset hypertension(＞20 weeks of gestation)and at least one other associated complication,including proteinuria,maternal organ dysfunction,or uteroplacental dysfunction.Recent studies have found that altered expression of many lncRNAs and miRNAs in the placenta is associated with the pathophysiological,which is involved in placental development and maternal immunity.In this article,we discuss the research progress of aspirin in the prevention of pre-eclampsia,aiming to providing a reference for the clinical prevention of gestational hypertension.
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