Effects of bupropion and ziprasidone on female patients with secondary depression after schizophrenia and their influence on cardiac function and cardiac metabolic markers
Objective To explore the efficacy of bupropion and ziprasidone in the treatment of female patients with post-schizophrenia depression,as well as the effects on cardiac function and cardiac metabolic in-dexes.Methods A total of 90 female patients with post-schizophrenia depression at the Seventh People's Hospi-tal of Wenzhou City from July 2021 to May 2023 were selected as the research subjects.They were randomly di-vided into a bupropion group and a ziprasidone group,with 45 cases in each group.In addition to antipsychotic medication,the bupropion group was treated with bupropion,whereas the ziprasidone group was treated with ziprasidone.The positive and negative symptom scale(PANSS),Hamilton Depression Scale(HAMD),and clinical efficacy were compared between two groups.The cardiac function indicators[left ventricular ejection fraction(LVEF),left atrial diameter(LAD),left ventricular end systolic diameter(LVSD),and left ventricular end diastolic diameter(LVEDD)],as well as cardiac metabolic indicators[lactate dehydrogenase(LDH),creatine kinase isoen-zyme(CK-MB),and aspartate aminotransferase(AST)]were observed in two groups.Results After two months of treatment,the HAMD score and PANSS score of the bupropion group were lower than those of ziprasidone group(P＜0.05),the total effective rate of the bupropion group was higher than that of ziprasidone group(P＜0.05);in terms of cardiac function,the LVEF,LAD,LVSD and LVEDD levels of the bupropion group were lower than those of the ziprasidone group(P＜0.05);and the LDH,CK-MB and AST levels of the bupropion group were lower than those of the ziprasidone group(P＜0.05).Conclusion Bupropion is more effective than ziprasidone on female pa-tients with post-schizophrenia depression.It can not only reduce the degree of depression as well as clinical symp-toms,but also promote the improvement of cardiac function and metabolism.
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