Effect of ateplase combined with low molecular weight heparin on blood gas analysis indicators and coagu-lation function in patients with pulmonary embolism
Objective To investigate the efficacy of ateplase combined with low molecular weight heparin in the treatment of pulmonary embolism patients.Methods A total of 90 patients with pulmonary embolism ad-mitted to the First Affiliated Hospital of Henan University of Science and Technology from July 2020 to September 2022 were divided into a control group and an observation group using a random number table method,with 45 cases in each group.The control group patients were treated with low molecular weight heparin,while the observa-tion group received combined treatment with ateplase on the basis of the above treatment.Both groups were treated for 14 days.The clinical efficacy,time to symptom disappearance,blood gas parameters[partial pressure of carbon dioxide(PaCO2),partial pressure of oxygen(PaO2)],coagulation function parameters[thrombin time(TT),prothrom-bin time(PT),activated partial thromboplastin time(APTT)and fibrinogen(FIB)],and adverse reactions were com-pared between two groups.Results Compared with the control group,the total effective rate in the observa-tion group was higher(P＜0.05).The time for chest pain,dyspnea,and cyanosis disappearance in the observation group was shorter than that in the control group(P＜0.05).Compared with the control group,the levels of PaCO2 and FIB in the observation group were lower,while the levels of PaO2,TT,PT,and APTTT were higher(P＜0.05).There was no statistical difference in adverse reactions between two groups(P＞0.05).Conclusion The combi-nation of ateplase combined with low molecular weight heparin can achieve significant results in the treatment of pulmonary embolism patients,helping to alleviate various clinical symptoms in a short period of time,while also improving blood gas indicators and coagulation function.It is safe and reliable,and worthy of promotion and appli-cation.
Pulmonary embolismTissue plasminogen activatorLow molecular weight heparinPro-thrombinBlood gas analysis
万方数据
维普
