Objective To investigate the characteristics of peripheral blood T lymphocyte subsets in patients with diabetes mellitus complicated with drug-resistant tuberculosis.Methods A total of 60 patients with diabetes complicated with tuberculosis(combined group)and 60 patients with simple tuberculosis(non-combined group)were selected from the Fourth People's Hospital of Taiyuan from November 2020 to March 2022,and 60 healthy subjects(healthy control group)at the same time,according to the drug sensitivity results,patients in the combined group were divided into the sensitive group(32 cases)and the drug-resistant group(28 cases),and the characteristics of peripheral blood T lymphocyte subsets of patients in each group were analyzed and compared.Results Compared with the healthy control group,CD4+％and CD4/CD8 ratio were decreased and CD8+％were increased successively in the non-combined group and combined group,the differences were statistically significant(P＜0.01).Compared with the sensitive group,CD4+％and CD4+/CD8+ratio were further decreased and CD8+％was increased in the drug-resistant group(P＜0.01).Conclusion The cellular immune dysfunction mediated by T lymphocyte subsets is a key factor in the occurrence of diabetes mellitus complicated with drug-resistant tuberculosis.The therapeutic strategies developed in this direction are expected to be a new way to effectively improve the condition and prognosis of patients.
关键词
糖尿病/结核,肺/结核,抗多种药物性/T淋巴细胞亚群
Key words
Diabetes mellitus/Tuberculosis,pulmonary/Tuberculosis,multid drug resistance/T lymphocyte subsets
维普
万方数据