Effect of vitamin D supplementation on the prevention of metabolic bone disease and humoral immune function in premature infants
Objective To explore the effect of vitamin D supplementation on the prevention of metabolic bone disease and humoral immune function in premature infants.Methods According to the random number table method,a total of 63 newborns born between January 2021 and January 2023 at Xuchang Maternal and Child Health Hospital were divided into a control group(31 cases)and an observation group(32 cases).Premature infants in the control group were given conventional oxygen inhalation,warmth retention and other treatments,and were fed with formula milk powder specifically designed for premature infants.While Premature infants in the ob-servation group received vitamin D supplementation treatment in addition to the above basic treatments.The growth and development indicators,bone metabolism indicators,immunoglobulin levels,and T lymphocyte subsets before and after treatment were compared between two groups.Results After treatment,the length,weight,and bone density of both groups of newborns increased,and the observation group[(47±4)cm,(3.2±0.7)kg,(2 890±344)g/cm2]showed a greater increase than the control group[(45±3)cm,(2.8±0.5)kg,(2 315±319)g/cm2](P＜0.05).There was no significant difference in the levels of serum phosphorus,serum calcium,serum 25 hydroxyvitamin D,and serum alkaline phosphatase in the control group of newborns before and after treatment(P＞0.05).After treat-ment,the serum phosphorus level of newborns in the observation group decreased significantly(1.89±0.09)mmol/L,and was lower than that in the control group(2.07±0.10)mmol/L;However,serum calcium,serum 25 hydroxyvita-min D,and serum alkaline phosphatase levels[(2.25±0.27)mmol/L,(32±6)nmol/L,(437±35)U/L]were significantly increased,and higher than the control group[(2.06±0.12)mmol/L,(26±4)nmol/L,(266±45)U/L](P＜0.05).There was no statistically significant difference in the levels of immunoglobulin A,immunoglobulin M,and immunoglobulin G between the two groups of newborns before and after treatment(P＞0.05).There was no significant difference in the levels of CD3+,CD4+,and CD8+among newborns in the control group before and after treatment(P＞0.05).After treatment,the levels of CD3+,CD4+,and CD8+in the observation group all increased,and the levels of CD3+and CD4+[(70±5)％,(40±3)％]were significantly higher than those in the control group[(64±4)％,(36±3)％](P＜0.05);However,there was no significant difference in CD8+levels between the two groups(P＞0.05).Conclusion Vita-min D supplementation can effectively promote the growth and development of premature infants,increase bone density,improve bone metabolism and calcium phosphorus metabolism,enhance cellular immune function,reduce the occurrence of metabolic bone diseases,and improve the prognosis of premature infants.However,the impact on immunoglobulin levels has not been effectively confirmed.
Infant,prematureSkeletonCalcitriolImmunity,humoralBone density
万方数据
维普
