Effect of dexamethasone on infection and nerve root injury after cesarean section in primipara with dif-ferent routes of administration
Objective To investigate the effects of different routes of dexamethasone administration on the C-reactive protein(CRP)and white blood cell count(WBC)in primiparous women after cesarean section,and to analyze whether dexamethasone can reduce puerperal infection and nerve root injury.Methods A total of 90 primiparous women who underwent cesarean section in Xinchang Hospital from June 2022 to June 2023 were selected and grouped according to whether dexamethasone was administered and the route of administration based on the random number table method.All patients were divided into Group E(epidural administration),Group Ⅰ(intravenous administration),and Group W(no administration).Group E received epidural injection of dexametha-sone 5 mg/2 ml two minutes after delivery of the umbilical cord,Group Ⅰ received intravenous injection of dexam-ethasone 5 mg/2 ml two minutes after delivery of the umbilical cord,and Group W did not receive dexamethasone.The CRP and WBC of each group were recorded and compared before surgery,2 days after surgery,and 4 days af-ter surgery.The occurrence of puerperal infection and nerve root injury symptoms in each group were also ob-served.Results Two days after surgery,the differences in CRP among the three groups of parturients were statis-tically significant(P＜0.05).Four days after surgery,the differences in CRP between Group E and Group Ⅰ,as well as between Group E and Group W,were statistically significant(P＜0.05),while the difference in CRP between Group Ⅰ and Group W was not statistically significant(P＞0.05).Two days after surgery,there were no statistically significant differences in WBC among the three groups of parturients(P＞0.05).Four days after surgery,there were no statistically significant differences in WBC between Group E and Group Ⅰ,as well as between Group Ⅰ and Group W(P＞0.05),while the difference between Group E and Group W was statistically significant(P＜0.05).There were statistically significant differences in puerperal infection among the three groups of parturients(P＜0.05),while there were no statistically significant differences in nerve root injury symptoms(P＞0.05).Conclusion Compared with intravenous administration,epidural administration of dexamethasone can more effectively normal-ize the abnormally elevated CRP and WBC in primiparous women after cesarean section.Both epidural and intra-venous administration of dexamethasone can reduce the incidence of puerperal infection and nerve root injury symptoms.
万方数据
维普
