Preventive effects and influencing factors of ceftriaxone compared to quinolone in the treatment of sys-temic inflammatory response syndrome among elderly patients undergoing prostate puncture surgery
Preventive effects and influencing factors of ceftriaxone compared to quinolone in the treatment of sys-temic inflammatory response syndrome among elderly patients undergoing prostate puncture surgery
Objective To explore the preventive effect and influencing factors of ceftriaxone and quinolone on systemic inflammatory response syndrome(SIRS)among elderly patients undergoing prostate punc-ture surgery.Methods A retrospective analysis was conducted on clinical data from 600 patients who underwent prostate puncture surgery at Zhejiang Provincial People's Hospital from March 2021 to October 2022.The patients were divided into two groups based on the prophylactic antibiotics administered prior to the puncture:Group A(n=285,receiving ceftriaxone)and Group B(n=315,receiving quinolones).The prophylactic effects of ceftriaxone and quinolones on SIRS were compared between Group A and Group B.Furthermore,based on clinical diagnosis,the patients were classified into two groups:the SIRS group(n=24)and the non-SIRS group(n=576),and impact factor analysis were conducted.Results The incidence of SIRS was significantly lower in Group A compared to Group B(25.0％vs 75.0％,respectively)(P＜0.05).There was a statistically significant difference between the SIRS group and the non-SIRS group in terms of the number of cases with a prostate volume greater than 45 ml,preoperative indwelling catheter,and diabetes(P＜0.05).Logistic regression analysis indicated that a prostate volume exceeding 45 ml,preoperative indwelling catheter,and diabetes were independent risk factors for SIRS in elderly patients undergoing prostate puncture(P＜0.05).Conclusion Compared with quinolones,the prophylactic administration of ceftriaxone demonstrates a superior effect in preventing SIRS among elderly patients undergoing prostate puncture.A prostate volume exceeding 45 ml,preoperative indwelling of a urinary catheter,and diabetes mellitus all play significant roles in influencing the occurrence of SIRS in this patient population.
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