Anesthetic effect of remazolam combined with nalbuphine in painless gastroenteroscopy
Objective To observe the clinical effect of Remazolam combined with nbuphine in painless gastroenteroscopy.Methods A total of 95 patients who underwent painless gastroenteroscopy between January 2022 and December 2022 in Xingxian People's Hospital were enrolled in the study.These patients were divided into two groups based on the method of medication:the propofol combined with nalbuphine group(PN group,47 cases)and the remazolam combined with nalbuphine group(RN group,48 cases).In the PN group,patients re-ceived a combination of propofol and nalbuphine,while in the RN group,patients received a combination of rema-zolam and nalbuphine.The respiratory rate(RR),heart rate(HR),oxygen saturation(SpO2),and mean arterial pressure(MAP)levels of both groups before,during,and after anesthesia were compared.Additionally,the onset time of anesthesia and recovery time for both groups were recorded.Furthermore,the occurrence of adverse reac-tions in both groups were analyzed.Results At the end of anesthesia and during recovery,patients in the PN group exhibited significantly lower RR,SpO2,and MAP levels compared to their pre-anesthesia values,while HR levels were significantly higher(P＜0.05).Conversely,in the RN group,RR and MAP levels were also significantly lower at the end of anesthesia and during recovery compared to preanesthesia levels(P＜0.05).Notably,at the end of anesthesia,patients in the RN group had lower HR levels and higher SpO2 levels compared to the PN group,with statistically significant differences(P＜0.05).Additionally,RR and MAP levels in the RN group were higher than those in the PN group at the end of anesthesia and during recovery,with statistically significant differences observed(P＜0.05).Regarding anesthetic onset,the RN group exhibited a significantly longer time of(1.7±0.2)minutes compared to the PN group's(1.2±0.3)minutes(P＜0.05).However,the RN group had a significantly short-er postoperative recovery time of(4.6±1.6)minutes compared to the PN group's(6.2±1.8)minutes(P＜0.05).Fur-thermore,the incidence rates of adverse reactions in the RN group were lower than those in the PN group.Specifi-cally,the RN group had significantly lower rates of injection pain(4％vs 32％),hypotension(13％vs 40％),respi-ratory depression(6％vs 19％),and dizziness(17％vs 38％)compared to the PN group,with statistically signifi-cant differences(P＜0.05).No significant difference was observed between the two groups in terms of nausea and vomiting incidence(P＞0.05).Conclusion In painless gastroenteroscopy,the anesthetic combination of rema-zolam and nalbuphine exhibits superior respiratory cycle stability compared to the use of propofol in con-junction with nalbuphine.Moreover,the former regimen elicits fewer adverse reactions,making it a highly recom-mendable anesthetic option worthy of widespread utilization
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