Analysis of affecting factors of adverse reactions in the treatment of osteoporosis with zoledronic acid and construction of nomogram prediction model
Objective To analyze the affecting factors of adverse reactions in the treatment of osteoporosis with zoledronic acid and construct a nomogram prediction model.Methods A total of 160 osteoporosis patients admitted to Yongkang Sixth People's Hospital from February 2019 to September 2021 were enrolled in this study.These patients were categorized into a study group(with adverse reactions,n=68)and a control group(without adverse reactions,n=92).The general characteristics of patients in both groups were observed,and the predictive value of statistically significant continuous variables was evaluated through ROC analysis.Logistic regression analysis was used to identify factors associated with the occurrence of adverse reactions in osteoporosis patients.Additionally,decision curve analysis was utilized to assess the clinical utility of the Nomogram model.Results There was no statistically significant difference between the two groups in terms of general information such as age and gender(P＞0.05).Compared to the control group,the study group exhibited less utilization of bone resorption inhibitors and calcium,a higher frequency of combined fractures,and lower levels of osteocalcin and calcium(P＜0.05).The A UC values for osteocalcin and calcium were 0.702 and 0.653,respectively,with 95％CI of(0.625,0.772)and(0.574,0.727),indicating their predictive value(P＜0.05).The use of bone resorption inhibitors,calcium intake,osteocalcin levels,and calcium levels were identified as the main factors influencing the occurrence of adverse reactions in osteoporosis patients(P＜0.05).Furthermore,a Nomogram model constructed based on these risk factors demonstrated a C-index of 0.740[95％CI:(0.706,0.774)]for predicting the risk of adverse reactions in osteoporosis patients.The risk threshold for this model was determined to be＞0.18.Conclusion The utilization of bone resorption inhibitors,calcium intake,as well as osteocalcin and calcium levels,are significant factors that contribute to the emergence of adverse effects in patients with osteoporosis.Furthermore,Nomogram modeling offers an enhanced assessment of the risk of adverse effects in these patients
OsteoporosisDrug-related side effects and adverse reactionsRoot cause analysisNomo-grams
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维普
