Effect of dydrogesterone combined with leuprolide acetate in the treatment of endometriosis after laparoscopic surgery
Objective To evaluate the efficacy of the combined administration of dydrogesterone and leuprorelin acetate in endometriosis patients who have undergone laparoscopic surgery.Methods A retrospective analysis was conducted out on 120 endometriosis patients who underwent laparoscopic surgery at Third People's Hospital of Cangnan County between January 2018 to January 2022.The patients were grouped into dydrogesterone,leuprorelin acetate,and a combined treatment group.This study evaluated the effects of dydrogesterone and leuprorelin acetate post-laparoscopy on serum levels of cancer antigen 125(CA125),vascular endothelial growth factor(VEGF),tissue inhibitors of metalloproteinases(TIMP),and monocyte chemoattractant protein-1(MCP-1).Additionally,it assessed menopausal symptoms(Kupperman score),pain intensity(visual analogue scale,VAS),overall treatment efficacy,and side effects.Results After treatment,all groups exhibited significant decreases in luteinizing hormone(LH),follicle-stimulating hormone(FSH),estradiol(E2),and prolactin(PRL)(P＜0.05).The combined group demonstrated lower levels of LH,FSH,and E2 compared to the other two groups(P＜0.05),with a notably greater decrease in E2 levels in the leuprorelin acetate group.However,no significant difference was observed in PRL levels among the groups.Serum levels of CA125,VEGF,TIMP,and MCP-1 in all groups dropped post-treatment compared to the baseline(P＜0.05),with the combined group showing lower levels than the other two groups(P＜0.05),though no significant difference was found between dydrogesterone and leuprorelin acetate groups.The combined group exhibited significantly lower Kupperman scores and VAS scores for symptoms like dysmenorrhea,pelvic pain,and pain during intercourse(P＜0.05).The overall effectiveness rate was highest in the combined group(95％)compared to the dydrogesterone(87％)and leuprorelin acetate groups(83％),with a significantly lower one-year recurrence rate(P＜0.05).Adverse reactions were lowest in the combined group(38％),significantly lower than in the other two groups(58％,60％),showing a statistically significant difference(P＜0.05).Conclusion The combined administration of dydrogesterone and leuprorelin acetate following laparoscopic surgery in patients with endometriosis effectively regulates hormone levels,alleviates pain symptoms,achieves remarkable clinical outcomes,reduces recurrence rates,and does not increase adverse reactions.
万方数据
维普
