Effects of modified Linggui Zhugan Decoction combined with naloxone on blood gas indicators and lung function in postoperative respiratory failure patients with lung cancer
Objective To explore the effect of modified Linggui Zhugan Decoction combined with nalox-one on blood gas indicators and lung function in postoperative respiratory failure patients with lung cancer.Methods A total of 140 patients with respiratory failure after lung cancer surgery admitted to Tongchuan People's Hospital from January 1,2020 to January 1,2023 were divided into a observation group and a control group de-pending on treatment method.The control group was treated with naloxone on the basis of routine treatment,while the observation group was treated with Linggui Zhugan Decoction on the basis of the control group.The therapeu-tic effects of the two groups were compared,and the clinical efficacy indexes and the occurrence of adverse reac-tions were observed.Before and after treatment,blood gas index,heart rate,respiratory rate and lung function in-dex were detected,and the score changes of anxiety and depression self-rating scale were evaluated.Results The duration of assisted ventilation[(5.4±2.7)d vs(9.6±3.2)d],average ICU observation time[(9±4)d vs(12±4)d],and mortality rate(7％vs 15％)in the observation group were significantly lower than those in the control group,while the success rate of one-time extubation(79％vs 52％)was higher than that in the control group(t/x2=12.413 1,7.342 8,15.697 4,3.179 1,P＜0.05).After treatment,the PaO2 in the observation group was significantly higher than that before treatment and the control group during the same period[(97.7±2.4)vs(90.5±3.6)],while the Pa-CO2[(43±6)vs(54±6)],heart rate[(82±8)times/min vs(91±9)times/min],and respiratory rate[(17±4)times/min vs(22±4)times/min]were significantly lower than those before treatment and the control group during the same period(t=15.450,11.300,8.249,8.751,P＜0.05).Additionally,the lung function indicators,anxiety score[(30±7)vs(46±9)],and self-rating depression scale score[(38±8)与(59±8)]in the observation group were significantly improved(t=9.226,7.209,7.829,8.869,13.298,18.420,P＜0.05).The total incidence of adverse reactions in the observation group was higher than that in the control group,but there was no statistical significance(P＞0.05).Conclusion On the basis of symptomatic supportive treatment,the combination of naloxone and Linggui Zhugan decoction can improve lung function,alleviate adverse emotions,avoid complications of auxiliary ventilation,reduce the frequen-cy and duration of auxiliary ventilation,stay in ICU for observation,and reduce mortality in patients with respira-tory failure after lung cancer surgery
NaloxoneLing Gui Zhu Gan TangLung NeoplasmsRespiratory insufficiency
万方数据
维普
