Comparison of clinical efficacy of duloxetine in the treatment of depression patients with different degrees of anxiety symptoms
Objective To explore the clinical efficacy of duloxetine in the treatment of depression patients with different degrees of anxiety symptoms.Methods A total of 100 patients with depression in the department of psychiatry of the Seventh People's Hospital of Wenzhou were selected.They were divided into a possible anxiety group of 36 cases(HAMA＜14 points)and a significant anxiety group of 64 cases(HAMA ≥ 14 points)according to the Hamilton Anxiety Scale(HAMA).Both groups were treated with duloxetine for a total of 8 weeks.The suicide risk,recurrence rate,and adverse reactions of the two groups were recorded,and their clinical efficacy,HAMA score,and Hamilton Depression Scale(HAMD)score were compared.Results The obvious anxiety group showed early efficacy after 2 weeks of treatment,and the effective rate and clinical cure rate after 4 and 8 weeks of treat-ment were significantly lower than those of the possible anxiety group(P＜0.05);There was no statistically signifi-cant difference in the incidence of adverse reactions between the two groups(P＞0.05).The suicide risk and recur-rence rate(61％,30％)of the obvious anxiety group were significantly higher than those of the possible anxiety group(28％,14％)(x2=18.452,P=0.001;x2=5.176,P=0.037).The HAMD and HAMA scores[(26±6),(21±6),(16±7),(11±6),(8±5)and(20.4±5.0),(18.9±4.8),(15.0±4.9),(12.6±4.4),(10.0±4.3)]of the obvious anxiety group were significantly higher than those of the possible anxiety group[(21±4),(16±4),(12±5),(9±4),(6±4)and(10.2±2.4),(9.3±2.7),(8.1±2.6)(7.3±2.3),(6.4±2.7)](t=6.348,P=0.001;t=5.176,P=0.001;t=4.982,P=0.001;t=5.749,P=0.001;t=3.157,P=0.011;and t=7.153,P=0.001;t=6.827,P=0.001;t=5.694,P=0.001;t=4.186,P=0.002;t=4.742,P=0.001)at admission and 1,2,4,and 8 weeks after treatment.The obvious anxiety group had early onset of treatment after 2 weeks,effective rates after 4 and 8 weeks,and clinical cure rates significantly lower than the possible anxiety group(P＜0.05).There was no statistically significant difference in the incidence of adverse reac-tions between the two groups(P＞0.05).Conclusion Duloxetine is more effective in the treatment of depression patients with different degrees of anxiety symptoms.The therapeutic effect is better for patients with mild anxiety symptoms.For depression patients with obvious anxiety symptoms,the risk of suicide is higher,the condition is more severe,and in the process of antidepressant treatment,the efficacy is worse,the onset is slower,and the re-currence rate is higher.Therefore,clinical attention should be strengthened.
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