Application effects of rh-bFGF treated artificial dermis in the repair of deep burn wounds in the upper limb
Objective To explore the application effects and safety of artificial dermis treated with recombinant human basic fibroblast growth factor(rh-bFGF)in the treatment of deep burn wounds in the upper limb.Methods A retrospective analysis was conducted on the clinical data of 54 patients with deep upper limb burns treated with artificial dermal transplantation in China Coast Guard Hospital of the People's Armed Police Force from February 2021 to February 2023.Among them,25 patients had their artificial dermis treated with physiological saline(control group),while the other 29 patients had their artificial dermis treated with rh-bFGF solution(observation group).The graft interval time,wound healing time,graft survival rate,clinical efficacy,complications,as well as the Quick upper limb function(Quick DASH)score and Vancouver Scar Scale(VSS)score before and after treatment were compared between the two groups.Results The interval time between skin grafting[(8.6±1.8)d and wound healing time[(9.3±3.3)d]in the observation group were significantly shorter than those in the control group[(12.9±2.8)d;(14.7±4.8)d](P＜0.05).The total effective rate of the observation group was significantly higher than that of the control group(97％vs.76％,P＜0.05).The Quick-DASH score and VSS score of the observation group were significantly lower than those of the control group at 3 and 6 months after treatment(P＜0.05).There was no significant difference in the survival rate of skin grafting(97％vs.80％)between the two groups(P＞0.05).Conclusion The artificial dermis treated with rh-bFGF can shorten the grafting and healing time of deep burn wounds in the upper limbs,improve clinical efficacy,and improve scar hyperplasia and upper limb function in patients
BurnsRecombinant human basic fibroblast factorDermisWound surfaceUpper extremity
万方数据
维普
