Clinical efficacy and safety of low molecular weight heparin in the treatment of recurrent abortion
Objective To investigate the clinical efficacy and safety of low molecular weight heparin in the treatment of recurrent abortion.Methods A total of 216 patients with recurrent miscarriage were included for retrospective analysis.All cases were from the First People's Hospital of Luohe City,selected from January 2019 to December 2021.According to different treatment methods,they were divided into group A(108 cases with conventional treatment)and group B(108 cases,treated with low molecular weight heparin combined with conventional treatment).The levels of hormone indexes,coagulation function indexes,full-term productivity,abortion rate,preterm birth rate and adverse reactions were compared between the two groups before and after treatment.Results After treatment,the levels of serum hormone indexes in both groups were increased compared with those before treatment,and those indexes in group B were increased compared with those in group A(t=8.499,15.076,6.422,all P＜0.05).After treatment,the platelet count and Fibrinogen(FIB)in both groups were decreased compared with that before treatment,and the above indexes in group B were lower than those in group A.After treatment,the activated partial thromboplastin time(APTT)in both groups was higher than before treatment,and the above indexes in group B were higher than those in group A(t=6.120,2.567,3.879,all P＜0.05).The term productivity of patients in group B was(53.7％)higher than that in group A(32.4％),while the abortion rate was(23.2％)lower than that in group A(41.7％)(x2=9.989,8.454,both P＜0.05).The preterm birth rate of patients in the two groups was 25.9％and 23.2％.There was no significant difference(x2=0.104,P＞0.05).Thrombocytopenia occurred in 7 patients in group A,accounting for 6.48％;Gingival bleeding occurred in 2 cases,accounting for 1.8％;There were 3 cases of ecchymosis(2.8％),and 11 cases of thrombocytopenia(10.2％)occurred in group B during treatment.Gingival bleeding occurred in 3 cases,accounting for 1.8％;There were 4 cases of ecchymosis,accounting for 3.70％.There was no significant statistical difference in the incidence of adverse reactions between the two groups(P＞0.05).Conclusion The application of low molecular weight heparin in recurrent abortion can improve term productivity,reduce the abortion rate,increase the levels of estrogen and progesterone,and promote the improvement of coagulation function without increasing adverse reactions.
万方数据
维普
