Effects of escitalopram combined with EEG biofeedback in the treatment of depression patients and its impact on serum cytokine levels
Objective To explore the efficacy of escitalopram combined with EEG biofeedback in the treatment of depression patients and its impact on serum cytokine levels.Methods A total of 80 patients with depression treated at Wenzhou Seventh People's Hospital from April 2021 to April 2023 were collected and divided into a control group and an observation group based on different treatment plans.Among them,the control group(39 cases)received treatment with escitalopram,while the observation group(41 cases)received treatment with escitalopram combined with EEG biofeedback.After 8 weeks of treatment,the efficacy of both groups was evaluated.The Hamilton Depression Rating Scale(HAMD)scores,Pittsburgh Sleep Quality Index(PSQI)scores,serum inflammatory cytokine levels,and neurological function related factor levels were compared between two groups before and 8 weeks after treatment.Results The total clinical effective rate of the observation group[93％(38/41)]is higher than that of the control group[77％(30/39)](x2=4.196,P＜0.05);The PSQI score of the observation group after treatment was lower than that of the control group[(9.4±1.6)points vs(11.7±2.0)points],(t=4.012,P＜0.05).After treatment,the levels of brain-derived neurotrophic factor(BDNF),serotonin(5-HT),norepinephrine(NE),and serotonin(5-HT)in the observation group were higher than those in the control group[(40±8)μg/ml,(11.0±2.0)μg/ml,(127±10)ng/ml]vs[(32±5)μg/ml,(8.4±1.6)μg/ml,(106±9)ng/ml](t=3.732,3.002,3.214,all P＜0.05).The levels of interleukin-8(IL-8),interleukin-2(IL-2),and tumor necrosis factor α(TNF)-α in the observation group were lower than those in the control group[(5.3±0.6)pg/ml,(4.5±0.8)μg/ml,(13.0±1.1)pg/ml]vs[(6.8±0.9)pg/ml,(5.2±1.1)μg/ml,(14.4±1.4)pg/ml](t=3.721,4.012,3.114,all P＜0.05).Conclusion The combination of escitalopram and EEG biofeedback therapy significantly improves serum cytokines in patients with depression,and has a definite therapeutic effect,which is worthy of clinical promotion.
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