Effect of ropivacaine combined with dexmedetomidine subarachnoid block anesthesia on elderly patients undergoing lower extremity orthopedic surgery
Objective To investigate the effect and influence of ropivacaine combined with dexmedetomi-dine subarachnoid block anesthesia in elderly patients undergoing lower extremity orthopedic surgery.Methods A total of 90 elderly patients were selected,all of whom underwent lower extremity orthopedic surgery in Tianjin Binhai New Area Hospital of Traditional Chinese Medicine,from January 2021 to December 2022.They were randomly divided into a control group(45 cases)and an observation group(45 cases)according to treatment meth-ods.The patients in the observation group were treated with ropivacaine plus dexmedetomidine for subarachnoid block anesthesia,while the patients in the control group were treated with ropivacaine plus sufentanil for sub-arachnoid block anesthesia.The hemodynamic changes including heart rate(HR),mean arterial pressure(MAP),and oxygen saturation(SpO2)before anesthesia and at various time points during anesthesia were compared be-tween the two groups.And the onset and duration of motor nerve block and sensory nerve block,the dose and fre-quency of the first use of analgesic drugs,comfort level,the levels of neuron-specific enolase(NSE)and S100-β central nervous system-specific protein at different time periods,and the incidence of adverse reactions such as dizziness,urinary retention,nausea and vomiting,and skin itching were compared between the two groups.Results There were no significant differences in hemodynamic indexes between the two groups(P＞0.05).Compared with the control group,the observation group had less data on the onset time for sensorimotor block,a longer duration,a higher BCS score,fewer uses of analgesic drugs,and a lower incidence of adverse reactions(P＜0.05).There was no statistical significance in the levels of NSE and S100-β between the two groups before anesthesia,30 min after surgery and at the end of surgery(P＞0.05).Conclusion Ropivacaine combined with dexmedetomidine in sub-arachnoid block anesthesia for elderly patients undergoing lower extremity orthopedic surgery has stable hemody-namics,and is more effective and safer than combined sufentanil,which has high application value.
万方数据
维普
