Clinical observation on the timing of systemic administration of ganciclovir in acute retinal necrosis syndrome
Objective To observe the visual effects and incidence of retinal detachment after systemic use of antiviral drug Ganciclovir at different times in acute retinal necrosis syndrome(ARNs),and to compare the effects of different systemic use of Ganciclovir on long-term visual acuity and retinal detachment in ARNs patients.Methods A retrospective case study was conducted to analyze the data of 22 cases(23 eyes)of ARNs admitted to Shanxi Eye Hospital from June 2018 to June 2023.According to the different time points when ganciclovir was administered for systemic use,all the patients were divided into group A(early treatment group,12 eyes,receiving ganciclovir within 2 weeks after onset)and group B(non-early treatment group,11 eyes,receiving ganciclovir after 2 weeks of onset).The follow-up time was 1-130 weeks.Results At the end of follow-up,the visual acuity(BCVA)of Group A was higher than that of Group B,with a statistically significant difference(Z=-2.069,P=0.037).The incidence of retinal detachment at the end of follow-up was 25％(3/12)in Group A,which was lower than 64％(7/11)in Group B,and the difference was statistically significant(P=0.036).Conclusion Early(within 2 weeks)systemic use of the antiviral drug Ganciclovir in ARNs patients has significantly improved long-term vision and re-duced the risk of retinal detachment compared to no early use(after 2 weeks)
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