Expression of mismatch repair proteins in colorectal cancer tissues and their relationship with clinical and pathological characteristics
Objective To analyze the expression of mismatch repair proteins in colorectal cancer tissues and their relationship with clinical pathological features,and to explore the value of mismatch repair protein detec-tion in clinical work.Methods Clinical and pathological data of 212 patients with colon and rectal cancer who underwent surgical treatment in the Department of Gastroenterology at First People's Hospital of Jining City from December 2021 to July 2023 were collected.The expression of MMR proteins MLH1,MSH2,MSH6,and PMS2 was analyzed,and dMMR was compared with other clinical and pathological data.Results Among 212 patients,there were 5 cases of MLH1 deficiency(2.4％),10 cases of PMS2 deficiency(4.7％),2 cases of MSH2 and MSH6 deficiency(0.9％),5 cases of MLH1 and PMS2 deficiency(2.4％),and 2 cases of MSH2 and MSH6 deficiency(0.9％).Among 212 cases of colorectal cancer,12 cases had dMMR,accounting for 5.7％;DMMR was not associ-ated with gender,age,degree of differentiation,TNM staging,T staging,N staging,presence or absence of vascular emboli,and presence or absence of nerve invasion in colorectal cancer patients;DMMR was related to tumor site and histological type(P＜0.05).Conclusion The deletion of mismatch repair protein expression is significantly correlated with tumor location and histological type.Detection of mismatch repair proteins can provide guidance for postoperative treatment plans and is of great significance for predicting the prognosis of cancer patients.
万方数据
维普
