Effect of glucocorticoids combined with goserelin acetate on the pregnancy rate of patients with en-dometriosis after laparoscopic surgery
Objective To explore the effect of glucocorticoids combined with noride on the pregnancy rate of patients with endometriosis after laparoscopic surgery.Methods According to the random number table method,a total of 83 patients with endometriosis who visited Nanyang Longhai Hospital from January 2022 to Jan-uary 2023 were divided into a control group(41 cases)and an observation group(42 cases).Both groups under-went laparoscopic surgery to remove the lesions 5～7 days after menstruation.After surgery,the control group re-ceived subcutaneous injection of goserelin acetate,while the observation group received oral methylprednisolone tablets in addition to the above.Both groups were treated continuously for six months.The clinical efficacy(clini-cal symptoms,signs,and pelvic mass condition),hormone levels(estradiol,follicle stimulating hormone,luteinizing hormone,vascular endothelial growth factor)before and after treatment,and inflammatory factors(C-reactive pro-tein,tumor necrosis factor-α,interleukin-2)levels before and on the third day after surgery,as well as pregnancy and recurrence status were compared between the two groups.Results After treatment,the efficacy in the obser-vation group was better(P＜0.05).The levels of estradiol,follicle-stimulating hormone,luteinizing hormone,and vascular endothelial growth factor in both groups were significantly reduced after treatment,and the relative reduc-tion in the observation group was greater(P＜0.05).Compared with preoperative,the levels of C-reactive protein,tumor necrosis factor-α,and interleukin-2 in both groups were significantly increased on the 3rd day after surgery,while the relative increase in the observation group was smaller(P＜0.05).The pregnancy rate was higher and the recurrence rate was lower in the observation group after treatment(P＜0.05).Conclusion The combination of glu-cocorticoids and goserelin acetate has a significant therapeutic effect on endometriosis,which can effectively regu-late hormone levels in patients,improve inflammatory reactions,and have outstanding effects on increasing preg-nancy rates and reducing disease recurrence rates.
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