Mechanism of lysine inositol vitamin B12 oral solution in the treatment of child anorexia based on network pharmacology
Objective To explore the mechanism of Lysine Inositol and Vitamin B12 Oral Solution in the treatment of children with anorexia based on network pharmacology.Methods By referring to the manual,the components of lysine inositol and vitamin B12 oral solution were excavated,and the correlation targets of compo-nents were predicted through Swiss Target Prediction website,and the intersection mapping was performed with the targets of anorexia,so as to obtain the therapeutic targets of pediatric anorexia.Protein interaction was used to screen the core targets,and molecular docking verification was carried out.Based on the common targets,func-tional annotation bioinformatics chip was used to analyze,and the key pathway of Lysine Inositol and Vitamin B12 oral solution in the treatment of pediatric anorexia was obtained.Results Lysine hydrochloride,inositol vitamin B12 were the main components in lysine inositol and vitamin B12 oral solution.A total of 40 target genes were predicted,among which 13 target genes were closely related to anorexism,mainly involving glutamate recep-tor signaling pathway,neuroactive ligand receptor interaction and other related molecular interactions.Conclusion lysine inositol and vitamin B12 oral solution may play a similar role to glutamate,and improve child anorexia by activating glutamate receptors in the postsynaptic membrane,which reflects the characteristics of mul-ti-component and multi-target synergistic action.
Network pharmacologyMolecular docking simulationChildAnorexiaLysine,inosite and vitamin B12 oral solutionMolecular mechanism
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