Effects of Dulaglutide combined with Metformin on obesity-related type 2 diabetes mellitus and its influ-ence on blood glucose variability and body mass
Objective To investigate the effect of Dulaglutide combined with Metformin on obesity-related type 2 diabetes mellitus(T2DM)and its influence on blood glucose variability(GV)and body mass.Methods A total of 100 patients diagnosed with obesity-related T2DM were selected at the Health Examination Center of Pinghu Second People's Hospital between March 2023 and October 2023,and were divided into an observation group(dulaglutide combined with metformin,n=50)and control group(treated with metformin,n=50)according to random sampling method and random sequence.The therapeutic effects,levels of glucose and lipid metabolism indicators,GV and physical indicators were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was significantly higher than that of the control group(94%vs 82%,P<0.05);There was a significant difference in serum glucose and lipid metabolism levels between the observation group and the control group[TC(4.12±0.41)vs(4.87±0.67)mmol/L,TG(2.51±0.36)vs(3.12±0.40)mmol/L,HDL-C(1.39±0.31)vs(1.05±0.27)mmol/L,LDL-C(2.05±0.26)vs(2.96±0.43)mmol/L,FPG(6.10±0.72)vs(8.24±1.12)mmol/L,FINS(5.02±0.51)vs(6.78±0.67)mmol/L]μU/ml(P<0.05);The mean amplitude of glycemic excursions(MAGE)and standard deviation(SD)of the observation group were lower than those of the control group[(2.65±0.38)vs(3.14±0.31)mmol/L,(1.45±0.52)vs(2.17±0.41)mmol/L](P<0.05);The body mass,BMI,and visceral fat thickness of the observation group were lower than those of the control group[(68.16±3.48)vs(71.16±3.46)kg,(24.57±0.89)vs(26.18±0.55)kg/m2,(25.68±1.32)vs(27.02±0.31)mm](P<0.05).Conclusion The treatment of dulaglutide combined with metformin has a good therapeutic effect on obesity-related T2DM,which can effectively improve glucose and lipid metabolism,GV,and body mass.
MetforminDulaglutideDiabetes mellitus,type 2Blood glucoseBody mass index
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