Effects of tirofiban hydrochloride combined with butylphthalide injection on clinical prognosis in patients with perforator artery cerebral infarction
Objective To analyze the clinical prognosis of tirofiban hydrochloride and butylphthalide in-jection in patients with perforator artery cerebral infarction,in order to provide a reference for the clinical treat-ment of patients with perforated artery cerebral infarction.Methods A total of 86 patients with perforator artery cerebral infarction in Anyang District Hospital were selected for prospective study.They were divided into a con-trol group(43 cases)and a study group(43 cases)with a method of random number table.The control group was treated with butylphthalide injection,while the study group was treated with tirofiban hydrochloride combined with butylphthalide injection.The therapeutic cycle of both groups was 2 weeks.The clinical effect of the two groups was compared:D-dimer,prothrombin time,and fibrinogen level before and after 2 weeks of treatment;cystatin C and homocysteine before and after 1 week and 2 weeks of treatment;modified rankin scale(mRS)and barthel in-dex(BI)after 1 and 2 weeks of treatment.Results After clinical treatment,there were 33 and 40 clinically effec-tive patients in the control group and the study group,respectively,accounting for 77%and 93%.There were more effective patients in the study group than in the control group(χ2=4.440,P=0.035).After 2 weeks of treatment,both groups showed lower D-dimer,fibrinogen than those before the treatment,and the decrease was more pronounced in the study group than that in the control group(t=27.371,6.088,all P<0.05),Prothrombin time was prolonged in both groups,and the prolongation in the study group was more pronounced than that in the control group(t=2.463,P<0.05).After 1 and 2 weeks of treatment,both groups showed lower cystatin C and homocysteine than those before the treatment,and the decrease in the study group was more significant than that in the control group(t=3.026,3.936,6.204,8.381,all P<0.05).After 2 weeks of treatment,both groups showed the decreased mRS scores and elevated BI scores compared to those treated 1 week,and the differences in mRS scores and BI scores of the study group were more significant than those of the control group(t=10.705,P<0.05;t=12.500,P<0.05).Conclusion Tirofiban hydrochloride combined with butylphthalein injection has a good clinical effect in the treatment of patients with perforator artery cerebral infarction,which can improve coagulation function to a certain extent,reduce vascular endothelial damage,and provide a basis for patients'future daily life.
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