Effects of levetiracetam with murine nerve growth factor for poststroke epilepsy on neural cytokines and cognitive function in patients
Objective To investigate the effect of levetiracetam combined with murine nerve growth fac-tor on neural cytokines and cognitive function in patients with epilepsy.Methods A total of 90 patients with post-stroke epilepsy admitted to Nanyang First People's Hospital from February 2021 to May 2023 were divided into control group(30 cases),intervention group(30 cases)and experimental group(30 cases)according to different treatment methods.The control group was treated with levetiracetam,the intervention group was treated with rat nerve growth factor,and the experimental group was treated with levetiracetam combined with rat nerve growth fac-tor for 1 month.The clinical efficacy of the 3 groups was compared,and the left middle cerebral artery blood flow,right middle cerebral artery blood flow,basilar artery blood flow,nerve cytokines[glial fibrillary acidic protein(GFAP),brain-derived neurotrophic factor(BDNF),S-100β protein(S-100β),neuron-specific enolase(NSE)]levels before and after treatment in 3 groups were compared.Levels of inflammatory factors[micrornA-222(miR-222),in-terleukin-6(IL-6)]and scores of cognitive functions[Montreal Cognitive Assessment Scale(MoCA),Mini Mental State Examination Scale(MMSE)]were measured before treatment and 2 and 4 weeks after treatment.Results After clinical treatment,the total effective rate of experimental group was higher than that of the control group and the intervention group(χ2=7.081,P<0.05).Left middle cerebral artery blood flow,right middle cerebral artery blood flow and basilar artery blood flow in the 3 groups after treatment were higher than before treatment,and the experimental group was higher than the control group and the intervention group(F=42.600,23.662,21.116,P<0.05).GFAP,S-100β and NSE in the 3 groups after treatment were lower than those before treatment.BDNF was higher than before treatment,the test group was lower than control group,and higher in test group than control group and intervention group(F=29.842,97.544,13.495,78.796,P<0.05).After 2 and 4 weeks of treatment,the levels of miR-222 and IL-6 in the 3 groups were lower than those before treatment,and the test group was higher than the control group and the intervention group(F=12.572,15.907,12.286,26.380,P<0.05).After 2 and 4 weeks of treatment,the scores of MoCA and MMSE in the three groups were higher than those before treatment,and the scores in the test group were higher than those in the control group and the intervention group(F=12.572,15.907,12.286,26.380,P<0.05).Conclusion Levetiracetam combined with rat nerve growth factor can improve the therapeutic effect,promote brain blood metabolism,improve nerve function,reduce the degree of inflammation and alleviate cognitive impairment in patients with post-stroke epilepsy.
StrokeEpliepsyLevetiracetamNerve growth factorNeural cytokinesCognition function
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