Effects of neurotrophic factor combined with tadalafil on erectile dysfunction in type 2 diabetes and on the expression levels of NGF,BDNF and VEGF
Objective To investigate the therapeutic effect of neurotrophic factor combined with tadalafil on erectile dysfunction in type 2 diabetes and its effect on the expression of NGF,BDNF and VEGF.Methods A retrospective study was conducted on 80 patients with type 2 diabetes mellitus and erectile dysfunction admitted to Longshan Hospital in Cixi City from May 2020 to June 2023.They were divided into a control group(treated with tadalafil,40 cases)and an observation group(treated with neurotrophic factors+tadalafil,40 cases)based on different treatment methods.The clinical efficacy,vascular endothelial function,serum neurotrophic factors,ejaculation function and sperm quality,erectile dysfunction index,erectile hardness,and sexual quality of life were compared between the two groups.Results After treatment,the clinical response rate in the observation group was higher than that in the control group(x2=4.581,P=0.032).After 8 weeks of treatment,the serum endothelin-1(ET-1)level in the observation group was lower than that in the control group,while 6-keto-prostaglandin F1a(6-keto-PGF1A),prostacyclin(PGI2),and VEGF were higher than those in the control group(t=8.057,P＜0.01;t=4.688,P＜0.01;t=2.538,P=0.013;t=3.969,P＜0.01).The levels of nerve growth factor(NGF),brain-derived neurotrophic factor(BDNF),and glial cell line-derived neurotrophic factor(GDNF)in the observation group were higher than those in the control group(t=2.094,P=0.039;t=2.124,P=0.037;t=2.876,P=0.005).The ejaculatory function scale(CI-PE)score in the observation group was higher than that in the control group,and the sperm count,sperm density,and sperm motility were all greater than those in the control group(t=2.459,P=0.016;t=2.821,P=0.006;t=3.370,P=0.001;t=4.181,P＜0.01).The erectile function index(IIEF-5),erectile hardness grading scale(EHGS),and sexual quality of life scale scores in the observation group were higher than those in the control group(t=6.242,P＜0.01;t=2.658,P=0.009;t=2.340,P=0.022).Conclusion The combined efficacy of neurotrophic factors and tadalafil for type 2 diabetes mellitus with erectile dysfunction has significant clinical efficacy,which can effectively improve vascular endothelial function and serum neurotrophic factor levels,enhance ejaculation and erectile function,and improve sexual quality of life,with good safety.
Nerve growth factorsTadalafilKidney deficiency and blood StagnationDiabetes mellitus,type 2Erectile dysfunction
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