Evaluation of intrathecal injection of vancomycin in the treatment of intracranial infection after intrac-erebral hemorrhage
Objective To analyze the effect of intrathecal injection of vancomycin on intracranial infec-tion in patients with intracranial hemorrhage after operation compared with meropenem.Methods The clinical data of 60 patients with intracranial infection treated in Jinzhong First People's Hospital of from March 2021 to January 2023 after the removal of intracerebral hematoma with small bone window were retrospectively analyzed.Patients were divided into study group and control group with 30 cases in each group according to different treat-ment plans.The study group was given vancomycin infusion+intrathecal injection,and the control group was given meropenem infusion+intrathecal injection.The clinical efficacy,cerebrospinal fluid glucose,intracranial pressure,body temperature and infection-related factors were compared between the two groups after treatment.Results The clinical effective rate of the study group was 97％,which was higher than that of the control group 73％,the difference was statistically significant(x2=4.706,P=0.030).Before treatment,the cerebrospinal fluid glu-cose,intracranial pressure and body temperature of the study group were not significantly different from those of the control group.There was no significant difference in white blood cell count(WBC),C-reactive protein(CRP),interleukin(IL)-6,tumor necrosis factor(TNF)-α between the two groups.After treatment,the cere-brospinal fluid glucose was increased in both groups,and the study group was higher than the control group(P＜0.001).The in-tracranial pressure(P=0.041)and body temperature(P=0.017)of both groups were decreased,and those in the study group was lower than those in the control group.WBC(P＜0.001),CRP(P=0.017),IL-6(P＜0.001)and TNF-α(P=0.011)were all decreased in both groups,and those of the study group was lower than those of the control group.Conclusion Vancomycin+intrathecal injection for postoperative intracranial infection after intracranial hemorrhage can effectively control intracranial infection in infected patients,which has a certain guid-ing value for clinical work.
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