Efficacy of cetirizine adjuvant therapy in improving small airway function and immune status in children with acute bronchial asthma
Objective To explore the effects of adjuvantive cetirizine therapy on small airway function and immune status in children with acute bronchial asthma.Methods A total of 84 children with acute bronchial asthma admitted to Changyuan Hospital of Traditional Chinese Medicine from October 2020 to October 2022 were included in the study.They were randomly divided into a control group(42 cases,treated with salbutamol sulfate inhalation solution)and a study group(42 cases,treated with salbutamol sulfate inhalation solution combined with cetirizine hydrochloride tablets)based on a random number table.Both groups of children underwent a 7-day treatment.The treatment effect,airway remodeling-related indicators,immune function indicators,inflammatory factor levels,and adverse reactions were compared between the two groups before and after treatment.Results The clinical total effective rate of the study group was 90％,which was higher than the 74％of the control group.After treatment,the levels of osteopontin(OPN),vascular endothelial growth factor(VEGF),matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1),immunoglobulin E(IgE),interleukin-4(IL-4),eosinophils(EOS),and exhaled nitric oxide(FeNO)in both groups decreased compared to before treatment,and the levels in the study group were lower than those in the control group(all P＜0.05).The total incidence of adverse reactions in the study group was 12％,while that in the control group was 19％,with no statistically significant difference(P＞0.05).Conclusion The adjuvantive theray of cetirizine in children with acute bronchial asthma can effectively inhibit airway remodeling,regulate immune function,and reduce inflammatory response,with significant therapeutic effects.Additionally,it does not increase adverse reactions and has good safety.
CetirizineAdjuvant therapyAsthmaAcute exacerbationAirway functionImmune status
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