Effect of hydrochlorothiazide combined with pulmonary surfactant on bronchopulmonary dysplasia and serum IL-6,CK-MB,CK and LDH levels in preterm infants
Objective To investigate the therapeutic effect of hydrochlorothiazide combined with pul-monary surfactant(PS)on bronchopulmonary dysplasia(BPD)in premature infants and its impact on serum inter-leukin-6(IL-6),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),and lactate dehydrogenase(LDH)lev-els.Methods A retrospective analysis was conducted on the data of 78 premature infants admitted to the neona-tal intensive care unit(NICU)of Zhoushan Women and Children's Hospital in Zhejiang Province from December 2020 to December 2023.The infants were divided into two groups based on different treatment regimens:those who received PS treatment(PS group)and those who received hydrochlorothiazide combined with PS treatment(PS+hydrochlorothiazide group).After propensity score matching,39 pairs of patients were obtained.After 72 hours of treatment,the clinical efficacy of the two groups was evaluated.The apnea time,oxygen inhalation time,mechani-cal ventilation time and hospital stay as well as changes of blood gas indicators[arterial blood potential of hydro-gen(pH),arterial partial pressure of carbon dioxide(PCO2),arterial partial pressure of oxygen(PO2)]and serum IL-6,CK CK-MB,and LDH before and after treatment were compared between groups.Results Compared with PS group,the improvement of total clinical effective rate in PS+hydrochlorothiazide group was more significant(95％vs 77％,P＜0.05).The apnea time,oxygen inhalation time,mechanical ventilation time and hospital stay in PS+hy-drochlorothiazide group were significantly shortened,and were shorter than those in PS group(P＜0.05).After treat-ment,the pH and PO2 of premature infants in PS+hydrochlorothiazidegroup were higher than those before treatment and those in PS group(P＜0.05)while the PCO2 was lower than that before treatment and that in PS group(P＜0.05).The levels of serum IL-6,CK,CK-MB,and LDH in both groups were significantly decreased after treatment compared to before treatment(P＜0.05),and the decreases in PS+hydrochlorothiazide group were more significant than those in PS group(P＜0.05).No obvious adverse reactions were observed in both groups.Conclusion Hy-drochlorothiazide combined with pulmonary surfactant has an exact efficacy in the treatment of premature infants with BPD,and can improve the clinical indicators and blood gas indicators,and reduce the levels of serum IL-6,CK CK-MB,and LDH so as to relieve the lung inflammation,and it has a protective effect on the development of nervous system and has good clinical safety.
HydrochlorothiazidePulmonary surfactantPremature infantsBronchopulmonary dys-plasiaBlood gas analysisInterleukin-6Creatine kinaseCreatine kinase isoenzymeLactate dehydrogenase
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