Clinical efficacy of Fuyuan Huoxue Decoction combined with artificial femoral head replacement in the treatment of elderly femoral intertrochanteric fractures
Objective To observe the clinical efficacy of Fuyuan Huoxue decoction combined with artificial femoral head replacement in treating elderly femoral intertrochanteric fractures.Methods A total of 120 elderly patients with femoral intertrochanteric fractures who were treated in the Huzhou Zhengbo Orthopedic Hospital were selected as the study subjects from February 2019 to February 2022,and they were divided into traditional Chinese medicine group(n=60)and western medicine group(n=60)by treatment.Both groups were treated with artificial femoral head replacement,and the western medicine was given conventional western medicine therapy after surgery,whereas the traditional Chinese medicine group was treated with conventional western medicine therapy and oral Fuyuan Huoxue decoction after surgery.The TCM symptom scores,hip joint function(Harris hip function,bone mineral density),fracture healing factors levels[exogenous bone morphogenetic protein(BMP),transforming growth factor-β(TGF-β1)]and hemorheology(erythrocyte rigidity index,whole blood high shear viscosity)before and after treatment,postoperative limb swelling degree and occurrence of complications were compared between the two groups.Results After 2 weeks after treatment,the scores of TCM symptom,erythrocyte rigidity index and whole blood high shear viscosity were decreased while the Harris hip function was increased compared to before treatment(P＜0.05).The bone mineral density,BMP and TGF-β1 were enhanced in the two groups compared with those before treatment(P＜0.05).Traditional Chinese medicine group had lower scores of TCM symptom[local distention:(1.67±0.53)vs(2.25±0.73);ecchymosis:(2.14±0.69)vs(2.58±0.81);pain(1.79±0.57)vs(2.36±0.77),erythrocyte rigidity index(5.47±0.72)vs(5.92±0.75)],whole blood high shear viscosity[(3.89±0.69)mPa·s vs(4.23±0.76)mPa·s,limb swelling degree 3 days after surgery(3.59±0.31 vs 4.07±0.35)and incidence rate of lower limb deep venous thrombosis(DVT)of lower(0％)vs(8.3％),and higher Harris hip function(60±6)vs(57±6),bone mineral density(0.83±0.11)g/cm3 vs(0.77±0.09)g/cm3,BMP(41±6)ng/ml vs(39±5)ng/ml and TGF-β,(395±96)μg/L vs(351±71)μg/L compared with those in western medicine group,and the difference was statistically significant(P＜0.05).There were no significant differences in the occurrence of other complications between the two groups(P＞0.05).Conclusion Fuyuan Huoxue decoction combined with artificial femoral head replacement can relieve the TCM symptoms of elderly patients with femoral intertrochanteric fractures and promote the fracture healing and hip function recovery,and it can also improve the postoperative limb swelling,and prevent the occurrence of DVT.
Fu Yuan Huo Xue TangArthroplasty,replacement,hipFemoral fractures
NETL
NSTL
万方数据
