Effects of Wenyang Jianpi Recipe combined with entecavir on decompensated hepatitis B cirrhosis and it influence on serum inflammatory factors and intestinal mucosal barrier function
Objective To investigate the efficacy of Wenyang Jianpi Recipe combined with entecavir in the treatment of decompensated hepatitis B cirrhosis.Methods From May 2020 to May 2022,148 patients with decompensated hepatitis B cirrhosis in Hangzhou Hanggang Hospital were selected and randomly divided into two groups by treatment.The control group(74 cases)received entecavir treatment,and the study group(74 cases)treated with Wenyang Jianpi prescription on this basis of te same treatment.The efficacy,liver function,hepatitis B virus,liver fibrosis indicators,inflammatory factors,intestinal mucosal barrier function related indicators,and adverse reactions were compared between the two groups.Results The total effective rate of the study group was 96％,which was higher than 85％of the control group(x2=5.049,P＜0.05).After treatment,the scores of TCM syndrome,AST,TBil,and ALT levels in both groups were lower than before treatment,and the study group[(4.2±1.1)scores,(55±8)U/L,(24±6)μmol/L,(48±5)U/L]was lower than the control group[(5.8±1.1)score,(64±11)U/L,(30±8)μmol/L,(78±8)U/L](t=9.055,5.494,6.107,27.095,P＜0.05).After treatment,hepatitis B virus DNA(HBV-DNA),HBV-DNA,type Ⅲ procollagen(PC-Ⅲ),laminin(LN)and hyaluronic acid(HA)in both groups were lower than those before treatment,and those in the study group[(1.5±0.3)×105 U/ml,(109±13)ng/ml,(130±12)ng/ml,(119±19)ng/ml]were lower than those in the control group[(2.0±0.5)×105 U/ml,(149±18)ng/ml,(181±15)ng/ml,(149±26)ng/ml](t=8.481,15.813,22.770,7.865,P＜0.05).After treatment,the level of TNF-α,IL-6 and hs-CRP in both groups were lower than before treatment,and the study group[(54±9)pg/ml,(96±18)pg/ml,(43±8)ng/L]was lower than the control group[(71±16)pg/ml,(117±26)pg/ml,(60±11)ng/L](t=8.152,5.712,10.729,P＜0.05).After treatment,the levels of diamine oxidase(DAO),D-lactate,and endotoxin in the study group[(5.2±0.6)U/L,(3.8±0.4)mmol/L,(0.21±0.05)EU/ml]were lower than before treatment and the control group[(6.4±0.7)U/L,(4.5±0.6)mmol/L,(0.27±0.07)EU/ml](t=10.979,7.886,6.000,P＜0.05).There was no significant difference in adverse reactions between the two groups(P＞0.05).Conclusion The prescription of Wenyang Jianpi Recipe combined with entecavir for decompensated hepatitis B cirrhosis has a definite curative effect,which can significantly reduce the level of inflammatory factors,repair intestinal mucosal barrier,inhibit virus replication,and the combination of drugs will not increase adverse reactions,ensuring safe medication.
Hepatitis BLiver cirrhosisWen Yang Jian Pi FangEntecavirTumor necrosis factor-alpha
万方数据
维普
