Effects of Rehmannia Yinzi combined acupuncture on cognitive dysfunction,hemodynamics,oxidative stress and serum MMP-9 and TIMP-1 after cerebral infarction
Objective To explore the effects of Dihuang Yinzi combined with acupuncture on cognitive dysfunction,hemodynamics,oxidative stress and serum matrix metalloproteinase-9(MMP-9),tissue inhibitor of metalloproteinase-1(TIMP-1)after cerebral infarction.Methods A total of 88 patients with convalescent cerebral infarction were selected as the study subjects between May 2021 and May 2022.According to treatment methods,these patients were assigned to the control group(47 patients)and the observation group(41 patients).Patients in the control group received conventional western medicine treatment,while patients in the observation group received Dihuangyinzi combined with acupuncture treatment in addition to the same western medicine treatment as the control group.Compare the clinical efficacy of the two groups of patients,as well as the changes in Mini-Mental State Examination(MMSE)scores,Montreal Cognitive Assessment(MoCA)scores,hemodynamics parameters[mean cerebral artery velocity(Vm),systolic velocity(Vs),and pulsatile index(PI)of the middle cerebral artery],oxidative stress response[superoxide dismutase(SOD),glutathione peroxidase(GSH Px),malondialdehyde(MDA)],and serum levels of MMP-9 and TIMP-1 before and 3 months after treatment the two group.Results ①The total effective rate of clinical treatment in the observation group was 96％(45/47),which was higher than that in the control group of 80％(33/41),P＜0.05;②After 3 months of treatment,MMSE and MoCA scores in both groups increased and the scores in the observation group were higher than the control group(P＜0.05);③Aft er 3 months of treatment,Vm and Vs levels in both groups increased and the levels in the observation group were higher than the control group,while PI levels in the both groups decreased and the level in the observation group was lower than the control group(P＜0.05);(4)After 3 months of treatment,SOD and GSH Px levels in both groups increased and the levels observation group was higher than the control group,while MDA levels in both groups decreased and the levels in the observation group was lower than the control group(P＜0.05);⑤After 3 months of treatment,MMP-9 levels in both groups decreased and the levels in the observation group was lower than the control group,while TIMP-1 levels in both groups increased and the levels in the observation group was higher than the control group(P＜0.05).Conclusion The combination of Dihuang Yinzi and acupuncture treatment for cerebral infarction patients can effectively improve cognitive dysfunction and hemodynamics,reduce oxidative stress,and enhance clinical efficacy.
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