Strain distribution and drug sensitivity in sputum samples of patients with COVID-19 compli-cated with bacterial infection
Objective To analyze the distribution of bacterial strains isolated from sputum samples of patients with COVID-19 complicated with bacterial infection,and their antibiotic susceptibility patternss.Methods This study collected relevant data of hospitalized patients diagnosed with COVID-19 pneumonia at our hospital between December 2022 and February 2023.The distribution of pathogenic bacteria in the sputum samples of these patients and their susceptibility to antibiotics was analyzed.Results A total of 1056 patients diagnosed with COVID-19 infection were included,among which 105 cases(9.94％)had positive bacterial cultures in their sputum samples.A total of 127 pathogenic bacterial strains were isolated,with Klebsiella pneumoniae,Acinetobacter bau-mannii,Escherichia coli,Pseudomonas aeruginosa,and Staphylococcus aureus accounting for 41.73％(53 cases),23.62％(30 cases),13.39％(17 cases),8.66％(11 cases),and 7.09％(9 cases)respectively.Klebsiella pneumoni-ae,Escherichia coli,and Pseudomonas aeruginosa showed high sensitivity to amikacin,ceftazidime,and cefopera-zone-sulbactam(＞80％).Acinetobacter baumannii demonstrated the highest sensitivity rate to piperacillin-tazobac-tam(50％).Staphylococcus aureus exhibited high sensitivity rates(＞80％)to ciprofloxacin,moxifloxacin,lev-ofloxacin,nitrofurantoin,gentamicin,vancomycin,and linezolid.Conclusion Some patients infected with the nov-el coronavirus may concurrently develop bacterial pneumonia,necessitating active identification of the causative pathogens and a rational selection of antibiotics sensitive to these pathogens.
万方数据
维普
