Effects of intestinal flora modulator combined with mirtazapine on poststroke depression and cerebral blood flow perfusion
Objective To investigate the therapeutic effect of intestinal flora modulator combined with mirtazapine on post-stroke depression(PSD)and the influence of cerebral blood flow perfusion.Methods A total of 122 PSD patients admitted to Wenzhou Seventh People's Hospital from January 2020 to March 2021 were se-lected as the research subjects.They were divided into two groups by treatment methods,with 61 cases in each group.The control group was treated with mirtazapine,while the combination group received intervention with gut microbiota regulators on the basis of the control group.The efficacy and cerebral blood flow perfusion indexes of the two groups were compared.Results After treatment,the number of intestinal flora,neuropeptide Y,and ADL scores in the combined group were higher than those in the control group(P＜0.05),while substance P,corticotropin releasing factor(CRF),and HAMD scores were lower than those in the control group(P＜0.05).The effective rate of combined therapy was higher than that of the control group(93％vs 80％)(x2=4.604,P=0.032).After treatment,the peak systolic velocity(PSV),mean systolic velocity(TMV)of the combined group were higher than those of the control group,while the resistance index(RI)was lower than that of the control group(P＜0.05).Conclusion The combined treatment of intestinal flora modulator and mirtazapine for post-stroke depression patients has a definite effect,which helps to rebuild the balance of intestinal flora,regulate the plasma neuropeptide level of patients,optimize cerebral blood flow perfusion,and has the value of promotion and application.
万方数据
维普
