Retrospective analysis of adverse drug reactions in a level ⅢA hospital from 2020 to 2023
Objective To analyze the characteristics and patterns of adverse drug reactions(ADR)in level Ⅲ A general hospital from 2020 to 2023,identify high-risk drugs,reduce clinical medication risks,and provide reference for rational drug use in clinical practice.Methods Retrospective analysis was carried out on 1 516 ADR reports collected and reported in Wenzhou People's Hospital from January 2020 to December 2023,and statistical analysis was conducted from the report number,reporter,ADR degree,patient gender,age,drug dosage form,route of administration,drug category,organ system involved and outcome.Results The number of ADR reports in 2022 was the highest(484 cases).A total of 898 cases(59.23％)were mainly doctors.There were 968 cases(63.85％)of general ADRs and 548 cases(36.15％)of new/severe ADRs.There were significant differences in the distribution of ADR report types among different years(x2=12.397,P＜0.05).The ratio of male to female ADR patients was 1.05∶1,and new/serious ADR in male group was slightly higher than that in female group(x2=11.086,P＜0.001).The proportion of patients over 70 years old was the highest(37.47％),and the proportion of new/serious ADR was also higher than that of other age groups(x2=39.368,P＜0.001).The number of ADR caused by injection was 473(44.92％).Up to 739 ADR cases(48.75％)were caused by intravenous infusion.The dosage forms of new/serious ADRs were mainly injection in 230 cases(41.97％),and intravenous administration in 249 cases(45.44％).The number of ADR cases caused by anti-infective drugs was 452(29.82％).Followed by cardiovascular system drugs 283 cases(18.67％);Among the ADRs caused by anti-infective drugs,quinolones accounted for the most 215 cases(47.57％),followed by β-lactam 169 cases(37.39％).Among the ADRs caused by cardiovascular drugs,antiplatelet drugs were 106(37.72％).The system/organs involved in ADR were mainly skin and subcutaneous tissue abnormalities in 290 cases(19.13％),and the new/severe ADR mainly showed physical reaction,digestive system and cardiovascular system.94.29％of the patients recovered or improved after ADR.Conclusion ADR monitoring should be further strengthened,especially for special populations and high-risk drugs,so as to improve clinical response to deal with ADR and promote clinical rational drug use.
Drug-related side effects and adverse reactionsMonitorRetrospective analysisHospitalsSafe medication
万方数据
维普
