Objective To investigate whether the use of proton pump inhibitors(PPIs)affects the clinical efficacy of tigecycline,and to provide clinical evidence for the combination of tigecycline and PPIs,thereby ex-ploring better clinical drug selection options.Methods A retrospective analysis was conducted on the clinical data of patients treated with tigecycline for anti-infection in Inner Mongolia People's Hospital from January 2020 to December 2023.Based on inclusion and exclusion criteria,a total of 306 patients were selected:161 patients in the tigecycline combined with proton pump inhibitors group(T+P group)and 145 patients in the tigecycline without proton pump inhibitors group(T group).The main outcomes included all-cause mortality and clinical efficacy.Sec-ondary outcomes included length of hospital stay,body temperature,and microbial clearance rate.Logistic regres-sion analysis was used to examine independent factors affecting clinical efficacy.Results The clinical effective rate in T+P group was lower than that in the T group(37.3％vs 49.7％),and the difference was statistically signifi-cant(x2=4.77,P=0.03).The average body temperature after treatment in the T+P group was higher than that in the T group[(37.1±0.8℃)vs(36.9±0.7℃)],and the difference was statistically significant(P=0.04).There was no statistical difference in all-cause mortality,microbiological clearance rate and hospital stay between the two groups.Multivariate Logistic regression analysis revealed that the combination of tigecycline and PPIs was an in-dependent risk factor affecting clinical efficacy[OR(95％CI):0.45(0.27,0.76),P＜0.01],suggesting that the proba-bility of clinical efficacy when tigecycline was combined with PPIs was 0.45 times that of tigecycline alone.The probability of gastrointestinal adverse reactions in the T+P group was higher than that in the T group(23.6％vs 13.8％),and the difference was statistically significant(P=0.03),while there was no difference in coagulation dysfunction between the two groups of patients.Conclusion The co-administration of PPIs during tigecycline anti-infection therapy may reduce clinical efficacy,but the specific mechanism remains unclear.Therefore,caution should be exercised when using PPIs in combination with tigecycline for anti infective treatment in clinical practice.
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