Causal relationship between circulating inflammatory factors and gastric cancer based on two sample Mendelian randomization analysis
Objective To investigate the potential causal relationship between 91 circulating inflammato-ry factors and gastric cancer using a two-sample Mendelian randomization analysis.Methods The pooled data of the genome-wide association study of 91 circulating inflammatory factors and gastric cancer were obtained from two different populations,and the genetic loci associated with 91 circulating inflammatory factors were selected as the instrumental variables exposed,and then the inverse variance-weighting method in the Mendelian randomiza-tion analysis method was used for analysis,and the sensitivity analysis was performed by Cochran's Q,MR-Egger intercept and MR-PRESSO methods.Results The results of inverse variance-weighted analysis showed that in-flammatory factors in the three central circulation were associated with gastric cancer.Tumor necrosis factor ligand superfamily member 12 levels(TNFSF12)was significantly associated with gastric cancer(OR(95％CI):0.629(0.459,0.861),P=0.004,adjust P=0.028].The other two circulating inflammatory factors had potential causal rela-tionships with gastric cancer,namely interleukin-12 subunit beta levels(IL-12β)[OR(95％CI):0.854(0.752,0.970),P=0.015,adjust P=0.345]and tumor necrosis factor-related activation inducers(TNF-related activation-induced cy-tokine levels,TRANCE)[OR(95％CI):0.765(0.608,0.964),P=0.023,adjust P=0.161],but not significant after cor-rection.Conclusion There is a positive causal relationship between tumor necrosis factor ligand superfamily members 12 and gastric cancer.
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