Comparison of the therapeutic effects of irbesartan and olmesartan medoxomil combined with conven-tional drugs on hypertension and their impact on liver and kidney function
Objective To investigate the efficacy comparison of irbesartan and olmesartan medoxomil combined with conventional drugs in the treatment of hypertension and their effects on liver and kidney function.Methods A total of 110 patients with hypertension were selected as research objects in Pingnan County General Hospital.The patient admitted to Pingnan County General Hospital,from January 2021 to December 2023.Accord-ing to different treatment plans,a total of 110 patients were divided into a control group and an observation group,with 55 cases in each group.The control group received treatment with irbesartan combined with conventional drugs,while the observation group received treatment with olmesartan medoxomil combined with conventional drugs.Compare the total effective rate of clinical treatment,blood pressure levels,alkaline phosphatase(ALP),as-partate aminotransferase(AST),alanine aminotransferase(ALT),microalbumin,serum creatinine,and adverse re-actions between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(96.4％vs 83.6％)(P＜0.05).Before treatment,there was no significant difference in the levels of daytime systolic blood pressure,daytime diastolic blood pressure,nighttime systolic blood pressure,and nighttime diastolic blood pressure between the two groups(P＞0.05).After treatment,the above blood pressure levels were significantly reduced in both groups,but the observation group was lower than the control group[(127±8)mmHg,(85±7)mmHg,(121±7)mmHg,(81±6)mmHg vs(133±8)mmHg,(92±7)mmHg,(129±8)mmHg,(89±6)mmHg](P＜0.05).Before treatment,there was no significant difference in alkaline phosphatase,aspartate amino-transferase,alanine aminotransferase,microalbumin,and serum creatinine between the two groups(P＞0.05).After treatment,the above indicators in both groups were significantly reduced,but the observation group was lower than the control group[(102.6±6.3)U/L,(24.3±2.6)U/L,(15.6±1.1)U/L,(25.9±3.8)mg/L,(80±8)mg/dl vs(121.5±7.6)U/L,(31.5±2.8)U/L,(17.6±1.3)U/L,(31.6±2.3)mg/L,(87±7)mg/dl](P＜0.05).The total incidence of adverse reactions such as headache,nausea,diarrhea,rash,joint pain,numbness,fatigue,etc.in the observation group was not sig-nificantly different from that in the control group(10.9％vs 14.6％)(P＞0.05).Conclusions Compared with irbe-sartan,olmesartan medoxomil is more effective in treating hypertension.It can effectively control blood pressure levels,protect liver and kidney function,and does not increase the risk of adverse reactions.
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