Objective To find out the problems in the dispensing and receiving process of hand-dis-pensed drugs in the ward pharmacy based on the PDCA cycle method and optimize the practice through the ap-plication of information technology.Methods We selected the reduction of the error rate in the dispensing and receiving of hand-dispensed drugs in the ward pharmacy as the measurement index,and use the fishbone diagram,Pareto diagram,and the 80/20 rule to analyze the causes of errors,and then carry out information-based optimiza-tion practices.Results The error rate of hand-dispensed drugs in the ward pharmacy during dispensing,trans-portation,and receiving has decreased from 0.28%to 0.12%,with a progress rate of 57.14%.Conclusion The application of PDCA cycle method can effectively optimize the whole process of dispensing,transportation,and re-ceiving of hand-dispensed drugs,ensure the safety of clinical diagnosis and treatment medications and promote the development of information management of hand-dispensed drugs in ward pharmacies.