Effects of Qinggan Huazhi decoction combined with polyene phosphatidylcholine capsules on liver fibrosis and steatosis in patients with non-alcoholic steatohepatitis
Objective To analyze the effect of Qinggan Huazhi Decoction combined with Polyene Phos-phatidylcholine Capsules in patients with non-alcoholic steatohepatitis(NASH).Methods A total of 106 NASH patients admitted to Huzhou First People's Hospital from June 2021 to June 2023 were selected and randomly di-vided into two groups using a random number table method.The control group(53 cases)received polyene phos-phatidylcholine capsules,while the study group(53 cases)were treated with Qinggan Huazhi decoction on the ba-sis of treatment in the control group.The clinical efficacy,biochemical indicators,inflammatory factors,liver fibro-sis,and steatosis indicators of the two groups were compared.Results The total effective rate of the study group(94％)was higher than that of the control group(79％)(x2=5.267,P＜0.05).After treatment,the levels of total bilirubin(TBIL),triglycerides(TG),alanine aminotransferase(ALT),and aspartate aminotransferase(AST)in the study group were lower than those in the control group(t=3.736,1.994,2.109,2.054,P＜0.05).The levels of IL-18,IL-37,and IL-6 in the study group were lower than those in the control group(t=9.067,1.998,2.056,P＜0.05).The levels of liver stiffness measurements(LSM),laminin(LN),type Ⅲ procollagen(PC Ⅲ),and fat attenuation parameter(FAP)in the study group were lower than those in the control group(t=2.235,2.099,18.770,2.044,P＜0.05).Conclusion The combination of Qinggan Huazhi Decoction and Polyene Phosphatidylcholine Capsules can improve the clinical efficacy of NASH patients,reduce serum TBIL,TG,ALT,and AST levels,alleviate inflamma-tory reactions,and reduce the degree of steatosis and liver fibrosis.
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