Clinical efficacy of different doses of nalbuphine combined with hydromorphone for patient-controlled intravenous analgesia after thoracoscopic radical resection of lung cancer
Objective To investigate the clinical efficacy of different doses of nalbuphine combined with hydromorphone for patient-controlled intravenous analgesia(PCIA)after radical resection of lung cancer under thoracoscope.Methods A total of 120 patients undergoing thoracoscopic radical resection of lung cancer in Longyou County People's Hospital of Zhejiang Province from January 2022 to December 2023 were vided into three groups by random number table method.Group A(n=40)received PCIA with nalbuphine 0.75 mg/ml+hy-dromorphone 25 μg/ml,group B(n=40)received nalbuphine 0.5 mg/ml+hydromorphone 50 μg/ml,and group C(n=40)received nalbuphine 0.25 mg/ml+hydromorphone 75 µg/ml.The numerical rating scale(NRS)scores in the resting and active states were observed and recorded at 4 h,8 h,12 h,24 and 48 h after surgery.The numerical rating scale(NRS)scores in resting state and active state,the total number of PCIA compressions,the number of effective compressions,the number of rescue analgesia,and the occurrence of adverse reactions were observed and recorded at different time points within 48 hours after operation.The patients'satisfaction with postoperative pain control was evaluated using the pain control satisfaction questionnaire(PTSS).Results Repeated measures analy-sis showed that NRS scores in resting state and active state measured at different time points were statistically dif-ferent(P＜0.05).There was no interaction between measurement time and group(P＞0.05).The results of variance analysis between the groups were statistically significant(P＜0.05),and the NRS scores in the resting and active states and the number of PCIA presses in group A were significantly higher than those in other groups at 8 h,12 h,24 h and 48 h after operation.The incidence of nausea and vomiting in group C was higher than that in group A and group B(P＜0.05).The difference in the number of rescue analgesia among the three groups was statistically significant,and the number of rescue analgesia in group A was the highest(P＜0.05).There were statistically sig-nificant differences in PTSS scores among the three groups,and the score of group B was higher than that of group A and group C(P＜0.05).Conclusion The PCIA regimen of nalbuphine 0.5 mg/ml+hydromorphone 50 μg/ml can achieve good analgesic effect and low incidence of adverse reactions in patients after radical resection of lung cancer under thoracoscope,which is worthy of clinical application.
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