Effects of amoxicillin combined with local minocycline on postoperative infection of implant teeth in patients with localized periodontitis and its impact on CRP,TNF-α,and IL-6 levels
Objective Exploring the efficacy of amoxicillin combined with local minocycline on postoper-ative infection of implant teeth in patients with localized periodontitis and its impact on inflammatory markers.Methods A total of 100 patients with localized periodontitis who underwent dental implantation in the depart-ment of stomatology in First People's Hospital of Jiande City,Zhejiang Province from June 2021 to June 2023 were randomly divided into a control group and an observation group using a random number table method,50 cases per group.The control group was treated with amoxicillin alone,while the observation group was treated with amoxi-cillin combined with minocycline.The clinical efficacy,periodontal indicators[modified gingival bleeding index(mSBI),periodontal probing depth(PD),and modified plaque index(mPLI)],serum inflammatory factors[high-sensitivity C-reac-tive protein(hs-CRP),tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)levels],as well as postoperative infections and complications were compared between the two groups.Results The total clinical ef-fective rate of the obser-vation group after treatment(92％)was significantly higher than that of the control group(74％)(P＜0.05);After treatment,the levels of hs-CRP(16±3)ng/L,TNF-α(16.1±2.6)ng/L,IL-6(2.0±0.5)ng/ml,as well as the incidence of postoperative infection(10％)and complications(6％)in the observation group were significantly lower than those in the control group[(30±4)mg/L,(20.0±3.2)ng/L,(3.8±1.0)ng/ml,28％and 22％](P＜0.05);After 3 months of re-pair,there was no significant difference in the levels of mSBI(0.81±0.38),PD(1.90±0.20)mm,and mPLI(0.68±0.10)between the observation group and the control group[(1.10±0.23),(2.74±0.15)mm,and(1.18±0.07)](P＞0.05).Conclusion The application of amoxicillin combined with minocycline ointment after dental im-plantation for the treatment of localized periodontitis has a good therapeutic effect,which can significantly reduce the patient's in-flammatory level and the incidence of postoperative infections,so it is worthy of further application.
万方数据
维普
