Effects of moxifloxacin combined with biapenem in the treatment of elderly patients with severe pneumo-nia and its influence on inflammatory factors,serum CD40L and VACM-1
Objective To investigate the curative effect of moxifloxacin combined with biapenem in the treatment of elderly patients with severe pneumonia and its influence on sex factors,serum tumor necrosis factor related activating protein(CD40L)and vascular cell adhesion molecule-1(VACM-1).Methods Using a prospective case-control analysis method,a total of 150 elderly patients with severe pneumonia admitted to Zhejiang Provincial People's Hospital,were selected and randomly divided into two groups,with 75 cases in each group.Among them,those treated with biapenem were taken as the control group,and those treated with moxifloxacin combined with biapenem were taken as the the combinated group.The efficacy,pathogen detection rate,inflammatory factors,serum CD40L and VACM-1 levels were compared between the two groups.Results The total clinical effective rate of the combined group was significantly higher than that of the control group(97％vs 79％),and the detection rate of pathogens after treatment was lower than that of the control group(x2=21.714,4.812,P＜0.05);The regression time of lung signs,cough,and asthma in the combined group were significantly shorter than that in the control group(t=4.751,P=0.018;t=4.369,P=0.023;t=5.134,P=0.007);After treatment,the levels of serum interleukin-6(IL-6),C-reactive protein(CRP),procalcitonin(PCT),CD40L,and VACM-1 in the combined group were lower than those in the control group(t=3.721,P=0.019;t=4.021,P=0.016;t=4.739,P=0.012;t=3.792,P=0.020;t=5.134,P=0.001);There was no significant difference in the incidence of adverse reactions between the combined group and the control group(x2=0.714,P=0.381).Conclusion The efficacy moxifloxacin combined with biapenem in the treatment of elderly patients with severe pneumonia was significant,the inflammatory reaponse of patients was significantly reduced,the expressions of serum CD40L and VACM-1 were significantly down-regulated,and the safety was high,which was worthy of recommendation.
MoxifloxacinBiapenemPneumoniaInflammatory factorsTumor necrosis factor related activator proteinVascular cell adhesion molecule-1
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