Safety evaluation of Chinese patent medicines in psychiatric hospitals
Objective To explore and analyze the causes and characteristics of adverse drug reactions(ADR)of Chinese patent medicines in psychiatric hospitals,and to propose corresponding improvement measures,with a view to providing valuable references for promoting clinical safety and rational drug use.Methods A ret-rospective analysis was conducted on a total of 59 ADR report data of Chinese patent medicines reported by Affi-filiated Mental Health Center of Jiangnan University from January 2022 to December 2022.Statistical analysis was carried out on aspects such as the gender and age of patients,the types of Chinese patent medicines,the method of administration and dosage form of drugs,the system or organ involved in ADR,the type and severity of ADR,the causality judgment of ADR,and the outcome.Results Among the 59 ADR reports of Chinese patent medicines,the ratio of male to female was 1∶1.03,the age was(64±17)years old,and the majority of patients were over 60 years old.A total of 8 categories and 28 types of Chinese patent medicines were involved,among which cardiovascular drugs accounted for the largest proportion(53％).Among the routes of administration that caused ADR,oral administration accounted for 53％.Among the systems(or organs)affected by ADR,systemic damage accounted for 22％.The incidence of new and serious ADRs accounted for 25％,of which new and serious ADR of Chinese patent medicine accounted for 3％.All the reported ADRs were closely associated with the Chinese patent medicines.If symptomatic treatment,drug withdrawal,dosage reduction,and other appro-priate measures were taken promptly after ADRs,the cure rate was 92％.Conclusion The ADRs caused by Chinese patent medicines are closely related to factors such as the patient's gender,age,types of Chinese patent medicines,routes of administration,and dosage forms.We should use Chinese patent medicine strictly according to the Doc-tor's advice,strengthen the monitoring of the patients with the high risk characteristics,pay more attention to the occurrence of new and serious ADR caused by Chinese patent medicine,and intervene in time,strengthen report-ing,training and education to ensure the clinical use of proprietary Chinese medicine more scientific,stan-dardized,safe,and reasonable.
Chinese patent drugsTraditional Chinese drug adverse reactionsRational drug use
万方数据
维普
