Effects of modified maxing ersan decoction combined with conventional western medicine on patients with acute exacerbation of COPD and its influence on airway inflammation
Objective To study the effects of modified maxing ersan decoction combined with conven-tional western medicine on patients with acute exacerbation of chronic obstructive pulmonary disease(COPD)and its influence on airway inflammation.Methods A total of 80 patients with acute exacerbation of COPD in the Shaoxing Hospital of Traditional Chinese Medicine from January 2021 to January 2024,According to the different treatment methods,they were divided into a western medicine group(n=33,conventional western medicine)and a Chinese-western medicine group(n=47,modified maxing ersan decoction on the basis of the western medicine group)according to the principles of non-randomized clinical concurrent control study and patient voluntarism.The courses of treatment for both groups were 10 days.The clinical efficacy,pulmonary function status,airway inflammation,and adverse reactions of the patients before and after treatment were compared between the two groups.Results The clinical effective rate of the Chinese-western medicine group was significantly higher than that of the western medicine group(98％vs 79％,x2=4.727,P＜0.05).After treatment,the symptom scores of cough,expectoration,dyspnea,and wheezing in the Chinese-western medicine group were significantly lower than those in the western medicine group[(1.94±0.36),(1.32±0.43),(1.87±0.48),(1.85±0.37)vs(2.36±0.43),(1.94±0.56),(2.13±0.41),(2.21±0.45)],(t=4.739,5.599,2.529,3.916,all P＜0.05).After treatment,the arterial partial pressure of oxygen(PaO2)and oxygen saturation(SaO2)in the Chinese-western medicine group were significantly higher than those in the western medicine group[(80.6±7.7)mmHg,(95.2±2.7)％vs(76.3±7.2)mmHg,(93.7±2.4)％](t=2.524,2.497,both P＜0.05).The partial pressure of carbon dioxide(PaCO2)in the Chinese-western medicine group was significantly lower than that in the western medicine group[(50±5)mmHg vs(54±5)mmHg](t=3.192,P＜0.05).After treatment,the vital capacity(VC),forced expiratory volume in 1 second(FEV 1),and peak expiratory flow(PEF)in the Chinese-western medicine group were significantly higher than those in the western medicine group[(2.08±0.43)L,(1.81±0.20)L,and(367±36)L/min vs(1.73±0.32)L,(1.65±0.24)L,and(335±36)Umin](t=3.965,3.242,2.846,all P＜0.05).After treatment,the levels of C-reactive protein(CRP),chitinase-3-like protein 1(CHI3L1),hypoxia-inducible factor-1α(HIF-1α),interleukin-6(IL-6),and interleukin-10(IL-10)in the Chinese-western medicine group were significantly lower than those in the western medicine group[(22.3±2.2)mg/L,(41±4)μg/L,(60±15)μg/L,(4.4±1.0)ng/L,and(4.5±1.2)pg/ml]vs[(32.4±2.7)mg/L,(49±4)μg/L,(80±16)μg/L,(5.4±1.4)ng/L,and(6.3±1.4)pg/ml](t=18.545,8.985,2.991,4.351,6.134,all P＜0.05).There was no statistically significant difference in the incidence of adverse drug reactions between the two groups(9％vs 6％,x2=0.168,P＞0.05).Conclusion Modified maxing ersan decoction combined with conventional western medicine has a signifi-cant effect in the treatment of patients with acute exacerbation of COPD.It can effectively alleviate the symptoms,improve pulmonary function and aiiway inflammation,with good safety.
Maxing Ersan decoctionPulmonary disease,Chronic obstructiveBlood gas analysisPul-monary functionTreatment outcomeInflammation
万方数据
维普
