Clinical efficacy of ambroxol injection combined with APRV for ARDS and its influence on respiratory mechanics and blood gas indexes of patients
Objective To investigate the clinical efficacy of ambroxol assisted airway pressure release ventilation(APRV)in the treatment of acute respiratory distress syndrome(ARDS),and to analyze the effects of this treatment on respiratory mechanics and blood gas indexes of patients.Methods This study was a prospective study.A total of 128 ARDS patients who received APRV treatment at Jinhua People's Hospital from January 2020 to December 2022 were selected.During the ventilation process,patients were divided into a control group and a study group according to different treatment methods,with 64 cases in each group.The control group received saline solution as adjuvant therapy,while the study group received ambroxol injection as adjuvant therapy.The efficacy,respiratory mechanics,and changes in blood gas indicators were analyzed and compared between the two groups.Results The total effective rate in the study group was significantly higher than that in the control group[90.6％(58/64)vs 76.6％(49/64),P＜0.05].After 3 days of treatment,both Pmean and Crs in both groups increased compared to before treatment,while Pplat decreased.Additionally,after treatment,Pmean and Crs in the study group were significantly higher than those in the control group,while Pplat was significantly lower(P＜0.05).According to the trend chart,there were significant fluctuations in blood gas indicators in both groups within 3 days of treatment,and there were statistical differences in the level of each indicator at different time points(P＜0.05).There was no statistical difference in blood gas indicators between the two groups before treatment and at 24 hours after treatment(P＞0.05).At 48 hours and 72 hours after treatment,both groups showed an increase in SaO2,PaO2,and PaO2/FiO2 compared to before treatment,while PaCO2 decreased.In addition,the study group had higher SaO2,PaO2,and PaO2/FiO2 and lower PaCO2 compared to the control group(P＜0.05).Conclusion APRV-assisted ventilation in the treatment of ARDS can help patients improve their symptoms.The combination of ambroxol therapy can enhance the overall clinical efficacy,and further improve respiratory mechanics and blood gas indicators.
Respiratory distress syndromeContinuous positive airway pressureAmbroxolTreatment outcomeRespiratory mechanicsBlood gas index
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维普
