Effects of modified Banxia Xiexin Decoction on oxidative stress,serum miR-155,and sIL-2R in patients with Helicobacter pylori-related gastritis
Objective To explore the effects of Banxia Xiexin Decoction on oxidative stress,serum miR-155,and sIL-2R in patients with Helicobacter pylori(Hp)-related gastritis.Methods A total of 94 patients with Hp-related gastritis who were diagnosed and treated in Linping District Hospital of Integrated Traditional Chinese and Western Medicine from January 2022 to December 2022 were selected and divided into two groups by ran-dom number table method,the control group(47 cases)and the study group(47 cases).The control group was treated with quadruple therapy,while the study group was treated with quadruple therapy plus Banxia Xiexin De-coction.The TCM syndrome scores,oxidative stress indicators,serum miR-155,sIL-2R,Hp negative conversion rate,clinical treatment efficacy and adverse reactions were compared between the two groups before and after treatment.Results Compared with before treatment,the TCM syndrome scores in both groups decreased after treatment(P＜0.05);and compared with the control group,the TCM syndrome scores in the study group were lower after treatment(P＜0.05).Compared with before treatment,NO and MDA levels in both groups decreased after treatment(P＜0.05),while SOD levels in both groups increased after treatment(P＜0.05).Moreover,compared with the control group,NO and MDA levels in the study group were lower after treatment(P＜0.05),and SOD levels in the study group were higher after treatment(P＜0.05).Compared with before treatment,the levels of miR-155 and sIL-2R in both groups decreased after treatment(P＜0.05).Furthermore,compared with the control group,the lev-els of miR-155 and sIL-2R in the study group were lower after treatment(P＜0.05).The Hp negative conversion rate in the study group was 87％,significantly higher than the 68％in the control group after treatment(x2=4.967,P＜0.05).The clinical treatment efficacy of the study group was better than that of the control group,and the total effective rate of treatment in the study group was 91％,significantly higher than the 74％in the control group(x2=4.821,P＜0.05).There was no statistically significant difference in the incidence of adverse reactions between the control group(9％)and the study group(6％)(x2=0.154,P＞0.05).Conclusion The combined treatment of quadru-ple therapy and Banxia Xiexin Decoction can effectively alleviate symptoms,reduce stress response,lower serum miR-155 and sIL-2R levels,improve Hp negative conversion rate and clinical treatment efficacy,with high safety
Ban Xia Xie Xin TangHelicobacter pyloriGastritisSoluble interleukin secondary re-ceptor
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